Ameliorative effects of quercetin against hepatic toxicity of oral sub-chronic co-exposure to aluminum oxide nanoparticles and lead-acetate in male rats

The present study was designed to evaluate the probable ameliorative role of quercetin (QCN) against oxidative hepatotoxicity induced by aluminum oxide nanoparticles (Al 2 O 3 NPs) with a diameter 

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 2023-04, Vol.396 (4), p.737-747
Main Authors: Abo-EL-Sooud, Khaled, Abd-Elhakim, Yasmina M., Hashem, Mohamed M. M., El-Metwally, Abeer E., Hassan, Bayan A., El-Nour, Hayat H. M.
Format: Article
Language:English
Subjects:
Acetates - pharmacology
Alanine transaminase
Alkaline phosphatase
Aluminum oxide
Aluminum Oxide - metabolism
Aluminum Oxide - toxicity
Animals
Antioxidants - metabolism
Antioxidants - pharmacology
Aspartate aminotransferase
Bilirubin
Biomedical and Life Sciences
Biomedicine
Chemical and Drug Induced Liver Injury - drug therapy
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - prevention & control
Cholesterol
Glutathione peroxidase
Hepatitis - metabolism
Hepatotoxicity
High density lipoprotein
Lead
Lead - metabolism
Lead - pharmacology
Lipid peroxidation
Lipoproteins (very low density)
Liver
Low density lipoprotein
Male
Nanoparticles
Neurosciences
Oxidative Stress
Pharmacology/Toxicology
Quercetin
Quercetin - pharmacology
Rats
Rats, Sprague-Dawley
Serum levels
Toxicants
Triglycerides
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Description
Summary:The present study was designed to evaluate the probable ameliorative role of quercetin (QCN) against oxidative hepatotoxicity induced by aluminum oxide nanoparticles (Al 2 O 3 NPs) with a diameter 
ISSN:0028-1298
1432-1912
DOI:10.1007/s00210-022-02351-y