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Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface
To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cyto...
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| Published in: | Doklady. Biochemistry and biophysics 2023-02, Vol.508 (1), p.12-16 |
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| container_end_page | 16 |
| container_issue | 1 |
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| container_title | Doklady. Biochemistry and biophysics |
| container_volume | 508 |
| creator | Ivanova, O. K. Sharapova, T. N. Romanova, E. A. Yashin, D. V. Sashchenko, L. P. |
| description | To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cytokine within 6 days causes the appearance of FasL, CD25, and LFA-1 proteins on CD8+CD25+ T lymphocytes, and also converts the LFA-1 protein into an active form having a high affinity for its target, ICAM-1 integrin. The appearance of these proteins on the surface of this subpopulation of lymphocytes allows them to induce programmed cell death in HLA-negative tumor cells. |
| doi_str_mv | 10.1134/S160767292270003X |
| format | article |
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K. ; Sharapova, T. N. ; Romanova, E. A. ; Yashin, D. V. ; Sashchenko, L. P.</creator><creatorcontrib>Ivanova, O. K. ; Sharapova, T. N. ; Romanova, E. A. ; Yashin, D. V. ; Sashchenko, L. P.</creatorcontrib><description>To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cytokine within 6 days causes the appearance of FasL, CD25, and LFA-1 proteins on CD8+CD25+ T lymphocytes, and also converts the LFA-1 protein into an active form having a high affinity for its target, ICAM-1 integrin. 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| ispartof | Doklady. Biochemistry and biophysics, 2023-02, Vol.508 (1), p.12-16 |
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| subjects | Antigens Antitumor activity Apoptosis Biochemistry Biochemistry, Biophysics, and Molecular Biology Biological and Medical Physics Biomedical and Life Sciences Biophysics CD25 antigen CD8 antigen CD8-Positive T-Lymphocytes Cell activation Cell death Cytokines FasL protein Humans Intercellular adhesion molecule 1 Interleukin 2 Interleukin-2 - metabolism LFA-1 antigen Life Sciences Lymphocyte Function-Associated Antigen-1 - metabolism Lymphocytes T Molecular Biology Surface antigens T-Lymphocytes - immunology Tumor cells |
| title | Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface |
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