Novel magnetic resonance KTRANS measurement of blood-brain barrier permeability correlated with covert HE

Using dynamic contrast-enhanced (DCE) MR perfusion and MR spectroscopy this study aimed to characterize the blood-brain barrier permeability and metabolite changes in patients with cirrhosis and without covert HE. Covert HE was defined using psychometric HE score (PHES). The participants were strati...

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Bibliographic Details
Published in:Hepatology communications 2023-04, Vol.7 (4)
Main Authors: Chaganti, Joga, Zeng, Georgia, Tun, Nway, Lockart, Ian, Abdelshaheed, Christina, Cysique, Lucette, Montagnese, Sara, Brew, Bruce J, Danta, Mark
Format: Article
Language:English
Subjects:
Blood-Brain Barrier - diagnostic imaging
Blood-Brain Barrier - metabolism
Blood-Brain Barrier - pathology
Brain - metabolism
Choline - metabolism
Glutamine - metabolism
Hepatic Encephalopathy
Humans
Inositol - metabolism
Liver Cirrhosis - pathology
Magnetic Resonance Spectroscopy
Male
Middle Aged
Original
Permeability
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Summary:Using dynamic contrast-enhanced (DCE) MR perfusion and MR spectroscopy this study aimed to characterize the blood-brain barrier permeability and metabolite changes in patients with cirrhosis and without covert HE. Covert HE was defined using psychometric HE score (PHES). The participants were stratified into 3 groups: cirrhosis with covert HE (CHE) (PHES
ISSN:2471-254X
2471-254X
DOI:10.1097/HC9.0000000000000079