Disseminated intravascular coagulation with renal and liver damage as the predominant manifestations of recurrent relapses in systemic juvenile rheumatoid arthritis

Relapses of systemic juvenile rheumatoid arthritis associated with intravascular coagulation are rare. This paper describes a patient who, over a two year period, had two relapses, each accompanied by evidence of liver and renal damage and disseminated intravascular coagulation. The patient was not...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 1992-03, Vol.51 (3), p.347-349
Main Authors: Schwartz, D, Averbuch, M, Pines, A, Kornovsky, R, Levo, Y
Format: Article
Language:English
Subjects:
Adult
Arthritis, Juvenile - complications
Arthritis, Juvenile - physiopathology
Biological and medical sciences
Diseases of the osteoarticular system
Disseminated Intravascular Coagulation - etiology
Disseminated Intravascular Coagulation - physiopathology
Female
Humans
Inflammatory joint diseases
Kidney - physiopathology
Kidney Diseases - etiology
Liver - physiopathology
Liver Diseases - etiology
Liver Function Tests
Medical sciences
Recurrence
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Summary:Relapses of systemic juvenile rheumatoid arthritis associated with intravascular coagulation are rare. This paper describes a patient who, over a two year period, had two relapses, each accompanied by evidence of liver and renal damage and disseminated intravascular coagulation. The patient was not receiving non-steroidal anti-inflammatory drugs, and all laboratory and clinical manifestations of her disease rapidly resolved after treatment with prednisone. It is therefore believed that the hepatocellular damage, in addition to the disseminated intravascular coagulation, was a direct manifestation of disease activity. A possible pathogenic role for tumour necrosis factor is suggested.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.51.3.347