HSPA5 Promotes the Proliferation, Metastasis and Regulates Ferroptosis of Bladder Cancer

Heat shock protein family A (HSP70) member 5 (HSPA5) is aberrantly expressed in various tumors and closely associated with the progression and prognosis of cancer. Nevertheless, its role in bladder cancer (BCa) remains elusive. The results of our study demonstrated that HSPA5 was upregulated in BCa...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-03, Vol.24 (6), p.5144
Main Authors: Wang, Qinghua, Ke, Shuai, Liu, Zelin, Shao, Haoren, He, Mu, Guo, Jia
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - genetics
Bladder cancer
Cancer
Cell cycle
Cell growth
Cell Line, Tumor
Cell Movement - genetics
Cell proliferation
Cell Proliferation - genetics
Development and progression
Ferroptosis
Ferroptosis - genetics
Growth factors
GRP78 protein
Heat shock proteins
Hsp70 protein
Humans
Medical prognosis
Metastases
Metastasis
p53 Protein
Prognosis
Proteins
Severe acute respiratory syndrome coronavirus 2
Signal transduction
Survival analysis
Therapeutic targets
Urinary Bladder Neoplasms - metabolism
Vascular endothelial growth factor
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Summary:Heat shock protein family A (HSP70) member 5 (HSPA5) is aberrantly expressed in various tumors and closely associated with the progression and prognosis of cancer. Nevertheless, its role in bladder cancer (BCa) remains elusive. The results of our study demonstrated that HSPA5 was upregulated in BCa and correlated with patient prognosis. Cell lines with low expression level of HSPA5 were constructed to explore the role of this protein in BCa. HSPA5 knockdown promoted apoptosis and retarded the proliferation, migration and invasion of BCa cells by regulating the VEGFA/VEGFR2 signaling pathway. In addition, overexpression of VEGFA alleviated the negative effect of HSPA5 downregulation. Moreover, we found that HSPA5 could inhibit the process of ferroptosis through the P53/SLC7A11/GPX4 pathway. Hence, HSPA5 can facilitate the progression of BCa and may be used as a novel biomarker and latent therapeutic target in the clinic.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24065144