A New Perspective for Potential Organ Damage Due to Iron-Mediated Oxidation in Thalassemia Major Patients

The aim of this study is to develop new perspectives to prevent or reduce potential organ damage due to iron-mediated oxidation in thalassemia major patients. Seventy patients were included in this study. Blood samples were taken from the patients before and after transfusion. Total thiol, native th...

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Bibliographic Details
Published in:Journal of clinical medicine 2023-03, Vol.12 (6), p.2422
Main Authors: Eren, Funda, Koca Yozgat, Ayça, Firat Oğuz, Esra, Neşelioğlu, Salim, Firat, Rıdvan, Gürlek Gökçebay, Dilek, Yarali, Hüsniye Neşe, Özbek, Namık Yaşar, Erel, Özcan
Format: Article
Language:English
Subjects:
Antioxidants
Automation
Blood diseases
Blood transfusions
Cardiovascular disease
Care and treatment
Chelation therapy
Clinical medicine
Complications and side effects
Correlation analysis
Diagnosis
Hemoglobin
Iron
Ischemia
Multiple organ failure
Oxidation
Oxidative stress
Physiology
Polyamines
Prevention
Risk factors
Software
Thalassemia
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Summary:The aim of this study is to develop new perspectives to prevent or reduce potential organ damage due to iron-mediated oxidation in thalassemia major patients. Seventy patients were included in this study. Blood samples were taken from the patients before and after transfusion. Total thiol, native thiol, disulfide, disulfide/native thiol percentage ratio, ischemia modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS), and ferroxidase levels were determined. Additionally, undepleted thiol level (UTL) was determined as a new parameter associated with organ damage. After transfusion, the levels of native thiol, total thiol, disulfide, TAS, ferroxidase, and TOS were higher, while the IMA levels and disulfide/native thiol percent ratio were lower. Significant correlations were found between antioxidant and oxidant tests before and after transfusion. Additionally, a negative correlation was found between the TOS and UTL levels of the patients measured before the transfusion. In the present study, transfusion therapy increased both oxidation and the antioxidant levels. In addition, the term UTL has been introduced as a parameter that enables the determination of the oxidation level that may cause potential organ damage in transfusion-dependent thalassemia patients.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12062422