A New Perspective for Potential Organ Damage Due to Iron-Mediated Oxidation in Thalassemia Major Patients

• Published in: Journal of clinical medicine 2023-03, Vol.12 (6), p.2422
• Main Authors: Eren, Funda, Koca Yozgat, Ayça, Firat Oğuz, Esra, Neşelioğlu, Salim, Firat, Rıdvan, Gürlek Gökçebay, Dilek, Yarali, Hüsniye Neşe, Özbek, Namık Yaşar, Erel, Özcan
• Format: Article
• Language: English
• Subjects: Antioxidants; Automation; Blood diseases; Blood transfusions; Cardiovascular disease; Care and treatment; Chelation therapy; Clinical medicine; Complications and side effects; Correlation analysis; Diagnosis; Hemoglobin; Iron; Ischemia; Multiple organ failure; Oxidation; Oxidative stress; Physiology; Polyamines; Prevention; Risk factors; Software; Thalassemia
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12062422

The aim of this study is to develop new perspectives to prevent or reduce potential organ damage due to iron-mediated oxidation in thalassemia major patients. Seventy patients were included in this study. Blood samples were taken from the patients before and after transfusion. Total thiol, native thiol, disulfide, disulfide/native thiol percentage ratio, ischemia modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS), and ferroxidase levels were determined. Additionally, undepleted thiol level (UTL) was determined as a new parameter associated with organ damage. After transfusion, the levels of native thiol, total thiol, disulfide, TAS, ferroxidase, and TOS were higher, while the IMA levels and disulfide/native thiol percent ratio were lower. Significant correlations were found between antioxidant and oxidant tests before and after transfusion. Additionally, a negative correlation was found between the TOS and UTL levels of the patients measured before the transfusion. In the present study, transfusion therapy increased both oxidation and the antioxidant levels. In addition, the term UTL has been introduced as a parameter that enables the determination of the oxidation level that may cause potential organ damage in transfusion-dependent thalassemia patients.