Antibodies to endothelial cells in Behçet's disease: cell-binding heterogeneity and association with clinical activity

OBJECTIVES--To investigate the prevalence and characteristics of antibodies to endothelial cells (aEC) from large vessel and from microvasculature in a group of patients with Behçet's disease (BD) to determine the relationship of these antibodies with clinical and laboratory features of the dis...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 1994-04, Vol.53 (4), p.265-267
Main Authors: Cervera, R, Navarro, M, López-Soto, A, Cid, M C, Font, J, Esparza, J, Reverter, J C, Monteagudo, J, Ingelmo, M, Urbano-Márquez, A
Format: Article
Language:English
Subjects:
Adipose Tissue - blood supply
Adult
Autoantibodies
Autoantibodies - analysis
Autoanticossos
Behcet Syndrome - immunology
Behçet's disease
Cells, Cultured
Central Nervous System Diseases - immunology
Endoteli
Endothelium
Endothelium, Vascular - immunology
Female
Humans
Immunoglobulines
Immunoglobulins
Malaltia de Behçet
Male
Microcirculation - immunology
Middle Aged
Prospective Studies
Thrombosis - immunology
Umbilical Veins - immunology
Uveitis - immunology
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Summary:OBJECTIVES--To investigate the prevalence and characteristics of antibodies to endothelial cells (aEC) from large vessel and from microvasculature in a group of patients with Behçet's disease (BD) to determine the relationship of these antibodies with clinical and laboratory features of the disease. METHODS--Thirty patients with BD were prospectively and consecutively studied. The aEC were determined by enzyme-linked immunosorbent assay (ELISA) using endothelial cells derived from human umbilical vein (large vessel) as well as from retroperitoneal adipose tissue (microvasculature). RESULTS--Fifteen patients (50%) had aEC, either directed to large vessel [8(26%) patients] or microvascular [13(43%) patients] endothelial cells. The percentage of active patients was significantly higher in the aEC-positive group [12(80%) patients] compared with the aEC-negative group [5(33%) patients] (p < 0.05). CONCLUSIONS--Patients with BD have a high prevalence of aEC when microvascular endothelial cells are used in the assay. These antibodies seem to be a marker of disease activity in this condition, previously considered as negative for autoantibodies.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.53.4.265