Vasculitis in patients with systemic sclerosis and severe digital ischaemia requiring amputation

OBJECTIVES--To document the incidence of histological vasculitis in amputation specimens from patients with severe digital ischaemia secondary to systemic sclerosis (SSc), and to look for an association between anticardiolipin (aCL) antibodies and severe digital ischaemia in SSc. METHODS--This was a...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 1994-05, Vol.53 (5), p.323-326
Main Authors: Herrick, A L, Oogarah, P K, Freemont, A J, Marcuson, R, Haeney, M, Jayson, M I
Format: Article
Language:English
Subjects:
Adult
Amputation
Antibodies, Anticardiolipin - blood
Arteries - pathology
Biological and medical sciences
Female
Fingers - blood supply
Fingers - surgery
Humans
Ischemia - etiology
Ischemia - surgery
Medical sciences
Middle Aged
Retrospective Studies
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Scleroderma, Systemic - complications
Scleroderma, Systemic - immunology
Vasculitis - etiology
Vasculitis - immunology
Vasculitis - pathology
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Summary:OBJECTIVES--To document the incidence of histological vasculitis in amputation specimens from patients with severe digital ischaemia secondary to systemic sclerosis (SSc), and to look for an association between anticardiolipin (aCL) antibodies and severe digital ischaemia in SSc. METHODS--This was a retrospective review of patients with SSc who underwent amputation for digital ischaemia over a three year period. RESULTS--Five of nine patients had histological vasculitis, four of whom had aCL antibodies, although these were not present in high titre. CONCLUSION--Vasculitis does occur in SSc, at least in that subgroup with severe peripheral ischaemia. These findings could have implications for treatment of this subgroup of patients with SSc.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.53.5.323