Cardiometabolic Care: Assessing Patients with Diabetes Mellitus with No Overt Cardiovascular Disease in the Light of Heart Failure Development Risk

The mechanisms leading to the development of heart failure (HF) in diabetes mellitus (DM) patients are multifactorial. Assessing the risk of HF development in patients with DM is valuable not only for the identification of a high-risk subgroup, but also equally important for defining low-risk subpop...

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Bibliographic Details
Published in:Nutrients 2023-03, Vol.15 (6), p.1384
Main Authors: Chrysohoou, Christina, Fragoulis, Christos, Leontsinis, Ioannis, Gastouniotis, Ioannis, Fragouli, Dimitra, Georgopoulos, Maximos, Mantzouranis, Emmanouil, Noutsou, Marina, Tsioufis, Konstantinos P
Format: Article
Language:English
Subjects:
Cardiomyopathy
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - etiology
Care and treatment
Complications and side effects
Congestive heart failure
Coronary vessels
Diabetes
Diabetes Mellitus
Diabetes Mellitus, Type 2 - complications
Ejection fraction
Fatty acids
Glucose
Heart failure
Heart Failure - etiology
Hemodynamics
Humans
Hyperglycemia
Hypertension
Kinases
Metabolic pathways
Metabolism
Oxidative stress
Patients
Phenotypes
Prevention
Prognosis
Proteins
Review
Risk
Risk assessment
Risk Factors
Risk groups
Structure-function relationships
Subgroups
Subpopulations
Triglycerides
Tumor necrosis factor-TNF
Vein & artery diseases
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Summary:The mechanisms leading to the development of heart failure (HF) in diabetes mellitus (DM) patients are multifactorial. Assessing the risk of HF development in patients with DM is valuable not only for the identification of a high-risk subgroup, but also equally important for defining low-risk subpopulations. Nowadays, DM and HF have been recognized as sharing similar metabolic pathways. Moreover, the clinical manifestation of HF can be independent of LVEF classification. Consequently, approaching HF should be through structural, hemodynamic and functional evaluation. Thus, both imaging parameters and biomarkers are important tools for the recognition of diabetic patients at risk of HF manifestation and HF phenotypes, and arrhythmogenic risk, and eventually for prognosis, aiming to improve patients' outcomes utilizing drugs and non-pharmaceutical cardioprotective tools such as diet modification.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15061384