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Cardiometabolic Care: Assessing Patients with Diabetes Mellitus with No Overt Cardiovascular Disease in the Light of Heart Failure Development Risk
The mechanisms leading to the development of heart failure (HF) in diabetes mellitus (DM) patients are multifactorial. Assessing the risk of HF development in patients with DM is valuable not only for the identification of a high-risk subgroup, but also equally important for defining low-risk subpop...
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| Published in: | Nutrients 2023-03, Vol.15 (6), p.1384 |
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| Main Authors: | , , , , , , , , |
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| container_issue | 6 |
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| container_title | Nutrients |
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| creator | Chrysohoou, Christina Fragoulis, Christos Leontsinis, Ioannis Gastouniotis, Ioannis Fragouli, Dimitra Georgopoulos, Maximos Mantzouranis, Emmanouil Noutsou, Marina Tsioufis, Konstantinos P |
| description | The mechanisms leading to the development of heart failure (HF) in diabetes mellitus (DM) patients are multifactorial. Assessing the risk of HF development in patients with DM is valuable not only for the identification of a high-risk subgroup, but also equally important for defining low-risk subpopulations. Nowadays, DM and HF have been recognized as sharing similar metabolic pathways. Moreover, the clinical manifestation of HF can be independent of LVEF classification. Consequently, approaching HF should be through structural, hemodynamic and functional evaluation. Thus, both imaging parameters and biomarkers are important tools for the recognition of diabetic patients at risk of HF manifestation and HF phenotypes, and arrhythmogenic risk, and eventually for prognosis, aiming to improve patients' outcomes utilizing drugs and non-pharmaceutical cardioprotective tools such as diet modification. |
| doi_str_mv | 10.3390/nu15061384 |
| format | article |
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Assessing the risk of HF development in patients with DM is valuable not only for the identification of a high-risk subgroup, but also equally important for defining low-risk subpopulations. Nowadays, DM and HF have been recognized as sharing similar metabolic pathways. Moreover, the clinical manifestation of HF can be independent of LVEF classification. Consequently, approaching HF should be through structural, hemodynamic and functional evaluation. Thus, both imaging parameters and biomarkers are important tools for the recognition of diabetic patients at risk of HF manifestation and HF phenotypes, and arrhythmogenic risk, and eventually for prognosis, aiming to improve patients' outcomes utilizing drugs and non-pharmaceutical cardioprotective tools such as diet modification.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu15061384</identifier><identifier>PMID: 36986114</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Cardiomyopathy ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Care and treatment ; Complications and side effects ; Congestive heart failure ; Coronary vessels ; Diabetes ; Diabetes Mellitus ; Diabetes Mellitus, Type 2 - complications ; Ejection fraction ; Fatty acids ; Glucose ; Heart failure ; Heart Failure - etiology ; Hemodynamics ; Humans ; Hyperglycemia ; Hypertension ; Kinases ; Metabolic pathways ; Metabolism ; Oxidative stress ; Patients ; Phenotypes ; Prevention ; Prognosis ; Proteins ; Review ; Risk ; Risk assessment ; Risk Factors ; Risk groups ; Structure-function relationships ; Subgroups ; Subpopulations ; Triglycerides ; Tumor necrosis factor-TNF ; Vein & artery diseases</subject><ispartof>Nutrients, 2023-03, Vol.15 (6), p.1384</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Assessing the risk of HF development in patients with DM is valuable not only for the identification of a high-risk subgroup, but also equally important for defining low-risk subpopulations. Nowadays, DM and HF have been recognized as sharing similar metabolic pathways. Moreover, the clinical manifestation of HF can be independent of LVEF classification. Consequently, approaching HF should be through structural, hemodynamic and functional evaluation. 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| subjects | Cardiomyopathy Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - etiology Care and treatment Complications and side effects Congestive heart failure Coronary vessels Diabetes Diabetes Mellitus Diabetes Mellitus, Type 2 - complications Ejection fraction Fatty acids Glucose Heart failure Heart Failure - etiology Hemodynamics Humans Hyperglycemia Hypertension Kinases Metabolic pathways Metabolism Oxidative stress Patients Phenotypes Prevention Prognosis Proteins Review Risk Risk assessment Risk Factors Risk groups Structure-function relationships Subgroups Subpopulations Triglycerides Tumor necrosis factor-TNF Vein & artery diseases |
| title | Cardiometabolic Care: Assessing Patients with Diabetes Mellitus with No Overt Cardiovascular Disease in the Light of Heart Failure Development Risk |
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