Hyponatremia as a Predictor of Cryptococcal Meningitis and Death Among Asymptomatic Persons With HIV and Cryptococcal Antigenemia

Abstract Among persons with human immunodeficiency virus–associated cryptococcal meningitis serum hyponatremia is a risk factor for mortality; however, the role of hyponatremia in persons with asymptomatic cryptococcal antigenemia is unknown. We found that serum hyponatremia ≤130 mmol/L is an indepe...

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Published in:Open forum infectious diseases 2023-03, Vol.10 (3), p.ofad156-ofad156
Main Authors: Lehman, Alice, Nalintya, Elizabeth, Wele, Abduljewad, Kirumira, Paul, Naluyima, Rose, Namuli, Teopista, Turya Musa, Fred, Skipper, Caleb P, Meya, David B, Boulware, David R, Rajasingham, Radha
Format: Article
Language:English
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Brief Report
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Summary:Abstract Among persons with human immunodeficiency virus–associated cryptococcal meningitis serum hyponatremia is a risk factor for mortality; however, the role of hyponatremia in persons with asymptomatic cryptococcal antigenemia is unknown. We found that serum hyponatremia ≤130 mmol/L is an independent risk factor for progression to meningitis and death in asymptomatic persons with cryptococcal antigenemia with low titers.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofad156