A Rare Occurrence of Opportunistic Infection by Streptococcus mitis Due to Antibiotic-Induced Neutropenia in Prosthetic Joint Infection

Prosthetic joint infection (PJI) is a devastating complication in arthroplasty surgery. Although the prevalence is less than 2%, its functional and financial implications are significant. Part of its treatment involves the usage of prolonged and high-dose systemic antibiotics. Ironically, this predi...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-02, Vol.15 (2), p.e35583
Main Authors: Tan, Eng Kee, Ahmad Hanif, Khairil Anwar, Jebasingam Issace, Samuel John, Che-Hamzah, Fahrudin
Format: Article
Language:English
Subjects:
Antibiotics
Case reports
Endocarditis
Infections
Infectious diseases
Knee
Microorganisms
Neutropenia
Neutrophils
Orthopedics
Pathogenesis
Patients
Prostheses
Streptococcus infections
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Summary:Prosthetic joint infection (PJI) is a devastating complication in arthroplasty surgery. Although the prevalence is less than 2%, its functional and financial implications are significant. Part of its treatment involves the usage of prolonged and high-dose systemic antibiotics. Ironically, this predisposes the patient to unwanted adverse effects caused by the drugs. We report a case of cefazolin-induced neutropenia that led to ( ) bacteraemia in a patient with PJI. There have been no previous reports on cefazolin-induced neutropenic bacteraemia complicating the treatment of PJI. This case report aims to create awareness among the attending physicians on the possibility of cefazolin-induced neutropenia, which led to bacteraemia from an opportunistic microorganism. The reversal was as simple as cessation of the antibiotic itself. However, if not recognized, it could be fatal.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.35583