Tremor, Daily Functioning, and Health-Related Quality of Life in Solid Organ Transplant Recipients

Solid organ transplant recipients (SOTR) frequently report tremor. Data concerning tremor-related impairment and its potential impact on health-related quality of life (HRQoL) are lacking. This cross-sectional study assesses impact of tremor on activities of daily living and HRQoL using validated qu...

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Bibliographic Details
Published in:Transplant international 2023-03, Vol.36, p.10951
Main Authors: Riemersma, Niels L, Kremer, Daan, Knobbe, Tim J, Gan, C Tji, Nolte, Svea, Gomes-Neto, António W, Blokzijl, Hans, de Meijer, Vincent E, Damman, Kevin, Eisenga, Michele F, Drost, Gea, Elting, Jan Willem J, Touw, Daan J, Berger, Stefan P, Bakker, Stephan J L, van der Stouwe, A M Madelein
Format: Article
Language:English
Subjects:
Activities of Daily Living
Cohort Studies
Cross-Sectional Studies
Female
Health Archive
Humans
Male
Middle Aged
Organ Transplantation
Quality of Life
Tacrolimus
Transplant Recipients
Tremor
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Summary:Solid organ transplant recipients (SOTR) frequently report tremor. Data concerning tremor-related impairment and its potential impact on health-related quality of life (HRQoL) are lacking. This cross-sectional study assesses impact of tremor on activities of daily living and HRQoL using validated questionnaires among SOTR enrolled in the TransplantLines Biobank and Cohort Study. We included 689 SOTR (38.5% female, mean [±SD] age 58 [±14] years) at median [interquartile range] 3 [1-9] years after transplantation, of which 287 (41.7%) reported mild or severe tremor. In multinomial logistic regression analyses, whole blood tacrolimus trough concentration was an independent determinant of mild tremor (OR per µg/L increase: 1.11, 95% CI: 1.02 to 1.21, = 0.019). Furthermore, in linear regression analyses, severe tremor was strongly and independently associated with lower physical and mental HRQoL (β = -16.10, 95% CI: -22.23 to -9.98, < 0.001 and β = -12.68, 95% CI: -18.23 to -7.14, < 0.001 resp.). SOTR frequently report tremor-related impairment of activities of daily living. Tacrolimus trough concentrations appeared as a main determinant of tremor among SOTR. The strong and independent association of tremor-related impairment with lower HRQoL warrants further studies into the effects of tacrolimus on tremor. : ClinicalTrials.gov, Identifier NCT03272841.
ISSN:1432-2277
0934-0874
1432-2277
DOI:10.3389/ti.2023.10951