A Randomized, Placebo-Controlled Crossover Study to Evaluate Postprandial Glucometabolic Effects of Mulberry Leaf Extract, Vitamin D, Chromium, and Fiber in People with Type 2 Diabetes

Introduction Reducing postprandial (PP) hyperglycemia and PP glucose excursions is important for overall glycemic management. Although most therapeutic lifestyle interventions that reduce caloric intake would affect this, there is no particular nutritional intervention favored. Methods We evaluated...

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Published in:Diabetes therapy 2023-04, Vol.14 (4), p.749-766
Main Authors: Mohamed, Mafauzy, Zagury, Roberto Luis, Bhaskaran, Kalpana, Neutel, Joel, Mohd Yusof, Barakatun Nisak, Mooney, Linda, Yeo, Lihe, Kirwan, Bridget-Anne, Aprikian, Olivier, von Eynatten, Maximilian, Johansen, Odd Erik
Format: Article
Language:English
Subjects:
Alfacalcidol
Calcifediol
Cardiology
Care and treatment
Chromium (Nutrient)
Diabetes
Endocrinology
Glucose
Health aspects
Hyperglycemia
Insulin
Internal Medicine
Materia medica, Vegetable
Medicine
Medicine & Public Health
Mulberry
Original Research
Plant extracts
Testing
Type 2 diabetes
Vitamin D
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Summary:Introduction Reducing postprandial (PP) hyperglycemia and PP glucose excursions is important for overall glycemic management. Although most therapeutic lifestyle interventions that reduce caloric intake would affect this, there is no particular nutritional intervention favored. Methods We evaluated the effects of a novel natural food adjuvant combining mulberry leaf extract (MLE) with other bioactive ingredients, in people with type 2 diabetes (T2D) originating from Asia, on improving PP glucometabolic response in a randomized controlled exploratory crossover, two-center study (USA, Singapore). A 2-g blend of 250 mg MLE [containing 12.5 mg of 1-deoxynojirimycin (DNJ)], fiber (1.75 g), vitamin D 3 (0.75 μg), and chromium (75 μg), compared with a similar blend without the MLE, was sprinkled over a 350-kcal breakfast meal (55.4 g carbs) and PP blood glucose (primary exploratory endpoint), insulin, and incretin hormones (GLP-1, GIP) were evaluated in blood samples over 3 h. Changes in incremental areas under the concentration curve (iAUC) and maximum concentrations ( C max ) were compared. Results Thirty individuals (12 women, mean age 59 years, HbA1c 7.1%, BMI 26.5 kg/m 2 ) were enrolled and the MLE-based blend relative to the blend without MLE significantly reduced glucose iAUC at 1 h (− 20%, p  
ISSN:1869-6953
1869-6961
DOI:10.1007/s13300-023-01379-4