Ultrastructural changes produced in rheumatoid synovial membrane by chrysotherapy

Biopsies of rheumatoid synovial membrane before and after chrysotherapy were examined with the light and electron microscopes, and subjected to electronprobe x-ray analysis. The main change noted was the occurrence of electron-dense deposits of characteristic morphology within pre-existing lysosomes...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 1976-02, Vol.35 (1), p.67-72
Main Authors: Ghadially, F N, Oryschak, A F, Mitchell, D M
Format: Article
Language:English
Subjects:
Adolescent
Aged
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - pathology
Electron Probe Microanalysis - methods
Female
Gold - analysis
Gold Sodium Thiomalate - pharmacology
Gold Sodium Thiomalate - therapeutic use
Humans
Lysosomes - ultrastructure
Male
Synovial Membrane - analysis
Synovial Membrane - drug effects
Synovial Membrane - ultrastructure
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Summary:Biopsies of rheumatoid synovial membrane before and after chrysotherapy were examined with the light and electron microscopes, and subjected to electronprobe x-ray analysis. The main change noted was the occurrence of electron-dense deposits of characteristic morphology within pre-existing lysosomes. Such deposits were also seen in other varieties of lysosomal bodies. X-ray analysis showed the presence of gold, phosphorus, osmium, and calcium in these deposits. The present study shows that gold enters the pre-existing lysosomes, supporting the concept that the beneficial effects of chrysotherapy are due to its action on the lysosome.
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.35.1.67