Multicentric validation of a prognostic tool for predicting brain death following out-of-hospital cardiac arrest in children

Out-of-hospital cardiac arrest (OHCA) in pediatric patients is associated with high rates of mortality and neurologic injury, with no definitive evidence-based method to predict outcomes available. A prognostic scoring tool for adults, The Brain Death After Cardiac Arrest (BDCA) score, was recently...

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Bibliographic Details
Published in:Resuscitation 2023-04, Vol.185, p.109727-109727, Article 109727
Main Authors: Henry, Matthew, Filipp, Stephanie L., Aydin, Elber Yuksel, Chiriboga, Nicolas, Zelinka, Kailea, Smith, Lorena Espinosa, Gurka, Matthew J., Irazuzta, Jose, Fonseca, Yudy, Winter, Meredith C., Pringle, Charlene
Format: Article
Language:English
Subjects:
Adult
Brain Death
Brain Death - diagnosis
Cardiopulmonary Resuscitation - methods
Child
Humans
Infant
OHCA
Out-of-Hospital Cardiac Arrest
Outcomes
Pediatric Critical Care
Pediatric OHCA
Post-Arrest Prognostication
Post-Resuscitation Care
Prognosis
Prognostication
Retrospective Studies
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Summary:Out-of-hospital cardiac arrest (OHCA) in pediatric patients is associated with high rates of mortality and neurologic injury, with no definitive evidence-based method to predict outcomes available. A prognostic scoring tool for adults, The Brain Death After Cardiac Arrest (BDCA) score, was recently developed and validated. We aimed to validate this score in pediatric patients. Retrospective cohort study of pediatric patients admitted to 5 PICUs after OHCA between 2011 and 2021. We extracted BDCA score elements for those who survived at least 24 hours but died as a result of their OHCA. We assessed score discrimination for the definitive outcome of brain death. Subgroup analysis was performed for infants 
ISSN:0300-9572
1873-1570
DOI:10.1016/j.resuscitation.2023.109727