Doctor trustworthiness influences pain and its neural correlates in virtual medical interactions

• Published in: Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2023-03, Vol.33 (7), p.3421-3436
• Main Authors: Anderson, Steven R, Gianola, Morgan, Medina, Natalia A, Perry, Jenna M, Wager, Tor D, Losin, Elizabeth A Reynolds
• Format: Article
• Language: English
• Subjects: Emotions; Humans; Magnetic Resonance Imaging; Original; Pain - diagnostic imaging; Patient Satisfaction; Physician-Patient Relations; Trust
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhac281

Abstract Trust is an important component of the doctor-patient relationship and is associated with improved patient satisfaction and health outcomes. Previously, we reported that patient feelings of trust and similarity toward their clinician predicted reductions in evoked pain in response to painful heat stimulations. In the present study, we investigated the brain mechanisms underlying this effect. We used face stimuli previously developed using a data-driven computational modeling approach that differ in perceived trustworthiness and superimposed them on bodies dressed in doctors' attire. During functional magnetic resonance imaging, participants (n = 42) underwent a series of virtual medical interactions with these doctors during which they received painful heat stimulation as an analogue of a painful diagnostic procedure. Participants reported increased pain when receiving painful heat stimulations from low-trust doctors, which was accompanied by increased activity in pain-related brain regions and a multivariate pain-predictive neuromarker. Findings suggest that patient trust in their doctor may have tangible impacts on pain and point to a potential brain basis for trust-related reductions in pain through the modulation of brain circuitry associated with the sensory-discriminative and affective-motivational dimensions of pain.