Primary Squamous Cell Carcinoma of Gallbladder With Hepatic Invasion

Squamous cell carcinoma of the gallbladder is a profoundly rare tumor. It is one of the most aggressive and deadly forms of gallbladder cancer, often being diagnosed at a later stage. There are no definitive risk factors described for this specific type of gallbladder tumor when compared to other fo...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-03, Vol.15 (3), p.e35795
Main Authors: Willson, Conner M, Barsoum, Nathalie, Khan, Mustafa Tamim Alam, Rushton, Jennifer
Format: Article
Language:English
Subjects:
Abdomen
Antigens
Cancer
Chemotherapy
Cytokeratin
Females
Gallbladder
Gallbladder cancer
Gallbladder diseases
Gallstones
General Surgery
Hemorrhage
Liver
Medical imaging
Medical prognosis
Metastasis
Oncology
Pathology
Radiation
Squamous cell carcinoma
Surgery
White people
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Summary:Squamous cell carcinoma of the gallbladder is a profoundly rare tumor. It is one of the most aggressive and deadly forms of gallbladder cancer, often being diagnosed at a later stage. There are no definitive risk factors described for this specific type of gallbladder tumor when compared to other forms of gallbladder carcinoma. This case is regarding a 64-year-old female who was found to have primary squamous cell carcinoma of the gallbladder during an attempted cholecystectomy. Her tumor was found to have invaded her liver. The tumor displayed characteristic qualities of a pure squamous cell carcinoma and was positive for CK7 and p63 upon pathological analysis. Best results for treatment for this condition are achieved via R0 resection. Adjuvant therapy with chemoradiation has not been well-defined nor very effective in prior cases.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.35795