Desmopressin as a hemostatic and blood sparing agent in bleeding disorders

Intranasal, subcutaneous, or intravenous desmopressin can be utilized to release von Willebrand Factor and Factor VIII into circulation, enhance platelet adhesion and shorten bleeding time. Due to these properties, desmopressin can be effective in controlling bleeding in mild hemophilia A, certain s...

Full description

Saved in:
Bibliographic Details
Published in:European journal of haematology 2023-05, Vol.110 (5), p.470-479
Main Authors: Mohinani, Ajay, Patel, Sarah, Tan, Virginia, Kartika, Thomas, Olson, Sven, DeLoughery, Thomas G., Shatzel, Joseph
Format: Article
Language:English
Subjects:
Bleeding
Blood
Coagulation factors
Deamino Arginine Vasopressin - therapeutic use
Desmopressin
Hematological diseases
Hemophilia
Hemorrhage - drug therapy
Hemorrhage - etiology
Hemorrhage - prevention & control
Hemostasis
Hemostatics - pharmacology
Hemostatics - therapeutic use
Humans
Hyponatremia
Liver diseases
transfusion
Uremia
von Willebrand Diseases - complications
von Willebrand Diseases - drug therapy
Von Willebrand factor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Intranasal, subcutaneous, or intravenous desmopressin can be utilized to release von Willebrand Factor and Factor VIII into circulation, enhance platelet adhesion and shorten bleeding time. Due to these properties, desmopressin can be effective in controlling bleeding in mild hemophilia A, certain subtypes of von Willebrand disease and in acute bleeding from uremia, end stage renal disease, and liver disease. Its use, however, can be complicated by hyponatremia and rarely arterial thrombotic events. While desmopressin has also been used as a prophylactic blood sparing agent in orthopedic, renal, and hepatic procedures, clinical studies have shown limited benefit in these settings. The purpose of this article is to review the evidence for desmopressin in primary hematologic disorders, discuss its mechanism of action and evaluate its utility as a hemostatic and blood sparing product in various bleeding conditions.
ISSN:0902-4441
1600-0609
DOI:10.1111/ejh.13930