Metabolomics meets systems immunology

Metabolic processes play a critical role in immune regulation. Metabolomics is the systematic analysis of small molecules (metabolites) in organisms or biological samples, providing an opportunity to comprehensively study interactions between metabolism and immunity in physiology and disease. Integr...

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Bibliographic Details
Published in:EMBO reports 2023-04, Vol.24 (4), p.e55747-n/a
Main Authors: Fu, Jianbo, Zhu, Feng, Xu, Cheng‐Jian, Li, Yang
Format: Article
Language:English
Subjects:
Biological properties
Biological samples
Computer applications
Data processing
EMBO10
EMBO19
EMBO21
Immunity
Immunology
Immunoregulation
infection
Life Sciences
Metabolites
Metabolomics
Multiomics
Regulatory mechanisms (biology)
Research Design
Review
Reviews
Sample preparation
Software
Statistical analysis
systems immunology
Workflow
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Summary:Metabolic processes play a critical role in immune regulation. Metabolomics is the systematic analysis of small molecules (metabolites) in organisms or biological samples, providing an opportunity to comprehensively study interactions between metabolism and immunity in physiology and disease. Integrating metabolomics into systems immunology allows the exploration of the interactions of multilayered features in the biological system and the molecular regulatory mechanism of these features. Here, we provide an overview on recent technological developments of metabolomic applications in immunological research. To begin, two widely used metabolomics approaches are compared: targeted and untargeted metabolomics. Then, we provide a comprehensive overview of the analysis workflow and the computational tools available, including sample preparation, raw spectra data preprocessing, data processing, statistical analysis, and interpretation. Third, we describe how to integrate metabolomics with other omics approaches in immunological studies using available tools. Finally, we discuss new developments in metabolomics and its prospects for immunology research. This review provides guidance to researchers using metabolomics and multiomics in immunity research, thus facilitating the application of systems immunology to disease research. Graphical Abstract This review discusses recent technological developments of metabolomic applications in immunological research and provides guidance to researchers using metabolomics and multiomics in an immunity context to apply systems immunology to disease research.
ISSN:1469-221X
1469-3178
DOI:10.15252/embr.202255747