Peritoneal mesothelioma and malignant lymphoma in mice caused by fibrous zeolite

Dust from the village of Karain containing the fibrous zeolite erionite, talc, and physiological saline were tested by intraperitoneal injection in 486 Swiss albino mice. Malignant tumours were found in 84 (41 mesotheliomas, 31 lymphomas, 1 peripheral epidermoid carcinoma, and 11 lymphomas and mesot...

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Bibliographic Details
Published in:British Journal of Industrial Medicine 1985-11, Vol.42 (11), p.746-749
Main Authors: Ozesmi, M, Patiroglu, T E, Hillerdal, G, Ozesmi, C
Format: Article
Language:English
Subjects:
Albinism
Aluminum Silicates - toxicity
Animals
Asbestos
Biological and medical sciences
Biopsies
Carcinogenesis, carcinogens and anticarcinogens
Chemical agents
Intraperitoneal injections
Lungs
Lymphoma
Lymphoma - chemically induced
Lymphoma - pathology
Medical sciences
Mesothelioma
Mesothelioma - chemically induced
Mesothelioma - pathology
Mice
Neoplasia
Peritoneal Neoplasms - chemically induced
Peritoneal Neoplasms - pathology
Talc - toxicity
Time Factors
Tuff
Tumors
Zeolites
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Summary:Dust from the village of Karain containing the fibrous zeolite erionite, talc, and physiological saline were tested by intraperitoneal injection in 486 Swiss albino mice. Malignant tumours were found in 84 (41 mesotheliomas, 31 lymphomas, 1 peripheral epidermoid carcinoma, and 11 lymphomas and mesotheliomas together) of the 321 animals which died spontaneously within nine to 32 months after injection of Karain dust (26.1%). Three mesotheliomas and no lymphomas were found among 24 animals injected in the same way with talc during the same time (12.5%). In 46 control animals injected with physiological saline three mesotheliomas and one lymphoma were seen (8.7%). Thus Karain dust appears to be a potent carcinogen, causing both mesotheliomas and malignant lymphomas.
ISSN:0007-1072
1351-0711
1470-7926
DOI:10.1136/oem.42.11.746