Human ventilatory response to washed and unwashed cottons from different growing areas

Thirty volunteer subjects were exposed to controlled amounts of respirable dust generated by the carding of cotton in an experimental cardroom. Eighteen exposures each lasting six hours were performed while carding unwashed and washed cottons from the three major growing regions of the United States...

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Bibliographic Details
Published in:British Journal of Industrial Medicine 1986-03, Vol.43 (3), p.182-187
Main Authors: Petsonk, E L, Olenchock, S A, Castellan, R M, Banks, D E, Mull, J C, Hankinson, J L, Bragg, K C, Perkins, H H, Cocke, J B
Format: Article
Language:English
Subjects:
Biological and medical sciences
Byssinosis
Byssinosis - etiology
California
Chemical and industrial products toxicology. Toxic occupational diseases
Cots
Cotton
Endotoxins
Endotoxins - analysis
Environmental Exposure
Forced Expiratory Volume
Geographic regions
Gossypium
Gravimetry
Humans
Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)
Linear regression
Lung - physiopathology
Medical sciences
Mississippi
Spirometry
Texas
Toxicology
Volunteerism
Washing
Water
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Summary:Thirty volunteer subjects were exposed to controlled amounts of respirable dust generated by the carding of cotton in an experimental cardroom. Eighteen exposures each lasting six hours were performed while carding unwashed and washed cottons from the three major growing regions of the United States. Elutriated dust was analysed gravimetrically and was comparable (0.59 mg/m3 +/- 0.04) for all exposures. Spirometry was recorded before and after each exposure. California cotton resulted in a significantly smaller fall in FEV1 than cotton of the same grade from Texas or Mississippi. All washed cottons resulted in reduced declines when compared with unwashed cottons. For 17 subjects breathing zone personal total dust samples were analysed for airborne endotoxin and compared with the individual's pulmonary function response. A significant correlation between endotoxin exposure and acute decrease in FEV1 was seen. The effect on FEV1 per nanogram of airborne endotoxin was greater for Mississippi cotton than for cotton from the other regions. Airborne endotoxin appears to be an important determinant of acute pulmonary effects of cotton dust. Water washing of cotton results in reduced airborne endotoxin and less bronchoconstriction.
ISSN:0007-1072
1351-0711
1470-7926
DOI:10.1136/oem.43.3.182