Recent developments in biosensing methods for extracellular vesicle protein characterization

Research into extracellular vesicles (EVs) has grown significantly over the last few decades with EVs being widely regarded as a source of biomarkers for human health and disease with massive clinical potential. Secreted by every cell type in the body, EVs report on the internal cellular conditions...

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Bibliographic Details
Published in:Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2023-01, Vol.15 (1), p.e1839-e1839
Main Authors: Suthar, Jugal, Taub, Marissa, Carney, Randy P, Williams, Gareth R, Guldin, Stefan
Format: Article
Language:English
Subjects:
Advanced Review
Advanced Reviews
Biomarkers
Biopsy
Biosensing
Biosensing Techniques
Biosensors
Exosomes - metabolism
Extracellular Vesicles - metabolism
Heterogeneity
Humans
In Vitro Nanoparticle‐Based Sensing
Nanoparticles
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Summary:Research into extracellular vesicles (EVs) has grown significantly over the last few decades with EVs being widely regarded as a source of biomarkers for human health and disease with massive clinical potential. Secreted by every cell type in the body, EVs report on the internal cellular conditions across all tissue types. Their presence in readily accessible biofluids makes the potential of EV biosensing highly attractive as a noninvasive diagnostic platform via liquid biopsies. However, their small size (50-250 nm), inherent heterogeneity, and the complexity of the native biofluids introduce challenges for effective characterization, thus, limiting their clinical utility. This has led to a surge in the development of various novel EV biosensing techniques, with capabilities beyond those of conventional methods that have been directly transferred from cell biology. In this review, key detection principles used for EV biosensing are summarized, with a focus on some of the most recent and fundamental developments in the field over the last 5 years. This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > In Vitro Nanoparticle-Based Sensing.
ISSN:1939-5116
1939-0041
DOI:10.1002/wnan.1839