LTβR Signaling Directly Controls Airway Smooth Muscle Deregulation and Asthmatic Lung Dysfunction

Deletion of LTβR in smooth muscle cells limits allergen-driven airway smooth muscle remodeling and airway hyperresponsiveness, implying that LTβR may control excessive bronchial smooth muscle activity related to remodeling and lung function impairment in asthma.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2022-12
Main Authors: Miki, Haruka, Kiosses, William B., Manresa, Mario C., Gupta, Rinkesh K., Sethi, Gurupreet S, Herro, Rana, Da Silva Antunes, Ricardo, Dutta, Paramita, Miller, Marina, Fung, Kai, Chawla, Ashu, Dobaczewska, Katarzyna, Ay, Ferhat, Broide, David H., Tumanov, Alexei V, Croft, Michael
Format: Article
Language:English
Online Access:Get full text
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Description
Summary:Deletion of LTβR in smooth muscle cells limits allergen-driven airway smooth muscle remodeling and airway hyperresponsiveness, implying that LTβR may control excessive bronchial smooth muscle activity related to remodeling and lung function impairment in asthma.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2022.11.016