Characterization of SHCBP1 to prognosis and immunological landscape in pan-cancer: novel insights to biomarker and therapeutic targets

Previous studies have revealed the significant roles of SHC SH2 domain-binding protein 1 (SHCBP1) in occurrence and progression of cancers, but there is no pan-cancer analysis of SHCBP1. In this study, we explored the potential carcinogenic role of SHCBP1 across 33 tumors from the TCGA and GTEx data...

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Published in:Aging (Albany, NY.) NY.), 2023-03, Vol.15 (6), p.2066-2081
Main Authors: Jiang, Fei, Shi, Yanlong, Wang, Yue, Ge, Chang, Zhu, Jun, Fang, Hanlu, Zhang, Yu, Zhang, Yixiao, Jian, Haokun, Lei, Tong, Lan, Sheng, Cao, Liyu, Yu, Hongzhu, Fang, Debao
Format: Article
Language:English
Subjects:
Biomarkers
Cell Cycle Proteins
Humans
Immunotherapy
Microsatellite Instability
Neoplasms - genetics
Prognosis
Research Paper
RNA, Messenger - genetics
Shc Signaling Adaptor Proteins
Tumor Microenvironment - genetics
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Summary:Previous studies have revealed the significant roles of SHC SH2 domain-binding protein 1 (SHCBP1) in occurrence and progression of cancers, but there is no pan-cancer analysis of SHCBP1. In this study, we explored the potential carcinogenic role of SHCBP1 across 33 tumors from the TCGA and GTEx databases. We investigated SHCBP1 expression, prognosis, genetic alterations, tumor mutational burden (TMB) score, microsatellite instability (MSI) and tumor microenvironment from TIMER2, GEPIA2, UALCAN and cBioPortal databases. Moreover, the cellular functions and potential mechanisms were evaluated by GO and KEGG analysis. Besides, the mRNA expression of SHCBP1 was examined using qRT-PCR assay in gastrointestinal cancers. SHCBP1 was significantly upregulated in various cancers, and apparent relationship existed between SHCBP1 and survival prognosis in patients. The TMB, MSI, and tumor microenvironment analysis indicated that SHCBP1 was closely related to immune checkpoints, immune targets, as well as CD4+ naive T cell, CD8+ T cell, and neutrophil. Moreover, the cellular functions of SHCBP1 were mainly in regulating cell cycle motor protein activity. In addition, we validated that SHCBP1 mRNA expression was over-expressed in gastrointestinal cancers. This study was the first to systematically determine the prognostic value of SHCBP1, providing a forward-looking perspective on immunotherapy and cellular processes in pan-cancer.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.204591