Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome

The effects of inhalations of an oxygen-xenon (70%/30%) mixture were studied in two models of acute respiratory distress syndrome caused by intratracheal administration of 0.5 mg/kg LPS or 0.04 ml acidin-pepsin (pH 1.2). Inhalation of the oxygen-xenon mixture inhibited the development and reduced th...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-03, Vol.174 (5), p.605-609
Main Authors: Fedorova, E. P., Filonova, M. V., Churin, A. A., Naumov, S. A., Nikiforov, P. E., Sandrikina, L. A., Evtushenko, D. N., Udut, E. V., Popov, O. S., Naumov, S. S., Fomina, T. I., Udut, V. V.
Format: Article
Language:English
Subjects:
Acute respiratory distress syndrome
Administration, Inhalation
Analysis
Animals
Antithrombin
Biomedical and Life Sciences
Biomedicine
Body weight
Cell Biology
E coli
Escherichia coli
Gases
Health aspects
Humans
Hypoxia
Inflammation
Inhalation
Internal Medicine
Laboratory Medicine
Lung
Lungs
Medical research
Medicine
Oxygen
Oxygen - pharmacology
Pathology
Pepsin
Pharmacology
Physiology
Research centers
Respiratory distress syndrome
Respiratory Distress Syndrome - drug therapy
Surfactants
Trachea
Xenon
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Summary:The effects of inhalations of an oxygen-xenon (70%/30%) mixture were studied in two models of acute respiratory distress syndrome caused by intratracheal administration of 0.5 mg/kg LPS or 0.04 ml acidin-pepsin (pH 1.2). Inhalation of the oxygen-xenon mixture inhibited the development and reduced the intensity of the inflammatory process in the lung tissue, which was assessed by the dynamics of lung weight and body weight of animals: the therapeutic exposure decreased both parameters. It was found that the thrombogenic stimulus, pathognomonic for the development of acute respiratory distress syndrome, decreased under the effect of oxygen-xenon inhalations, while the level of natural anticoagulant antithrombin III increased.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-023-05755-9