Neuroimaging and immunological features of neurocognitive function related to substance use in people with HIV

This study sought to identify neuroimaging and immunological factors associated with substance use and that contribute to neurocognitive impairment (NCI) in people with HIV (PWH). We performed cross-sectional immunological phenotyping, neuroimaging, and neurocognitive testing on virally suppressed P...

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Bibliographic Details
Published in:Journal of neurovirology 2023-02, Vol.29 (1), p.78-93
Main Authors: Murdoch, David M., Barfield, Richard, Chan, Cliburn, Towe, Sheri L., Bell, Ryan P., Volkheimer, Alicia, Choe, Joyce, Hall, Shana A., Berger, Miles, Xie, Jichun, Meade, Christina S.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cognition
Cross-Sectional Studies
HIV Infections - complications
Humans
Immunology
Infectious Diseases
Neuroimaging
Neurology
Neurosciences
Substance-Related Disorders - complications
Virology
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Summary:This study sought to identify neuroimaging and immunological factors associated with substance use and that contribute to neurocognitive impairment (NCI) in people with HIV (PWH). We performed cross-sectional immunological phenotyping, neuroimaging, and neurocognitive testing on virally suppressed PWH in four substance groups: cocaine only users (COC), marijuana only users (MJ), dual users (Dual), and Non-users. Participants completed substance use assessments, multimodal MRI brain scan, neuropsychological testing, and blood and CSF sampling. We employed a two-stage analysis of 305 possible biomarkers of cognitive function associated with substance use. Feature reduction (Kruskal Wallis p -value 
ISSN:1355-0284
1538-2443
DOI:10.1007/s13365-022-01102-2