Hemostatic Agents in Orthopedic Surgery

Controlling blood loss is a crucial aspect of orthopedic surgery. Hemostatic agents can be used intraoperatively in combination with antifibrinolytics as part of an overall strategy to limit blood loss. Several new hemostatic agents have recently come to the market designed specifically for vascular...

Full description

Saved in:
Bibliographic Details
Published in:HSS Journal 2023-05, Vol.19 (2), p.247-253
Main Authors: Tanghe, Kira K., Chalmers, Brian P., Blevins, Jason L., Figgie, Mark P., Carli, Alberto V., Agrusa, Christopher J., Sculco, Peter K., Gausden, Elizabeth B.
Format: Article
Language:English
Subjects:
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c396t-ce5236d33a97a626824aa23bd0e7f692487341ec47e6e6e53e1c98f3760558bb3
cites cdi_FETCH-LOGICAL-c396t-ce5236d33a97a626824aa23bd0e7f692487341ec47e6e6e53e1c98f3760558bb3
container_end_page 253
container_issue 2
container_start_page 247
container_title HSS Journal
container_volume 19
creator Tanghe, Kira K.
Chalmers, Brian P.
Blevins, Jason L.
Figgie, Mark P.
Carli, Alberto V.
Agrusa, Christopher J.
Sculco, Peter K.
Gausden, Elizabeth B.
description Controlling blood loss is a crucial aspect of orthopedic surgery. Hemostatic agents can be used intraoperatively in combination with antifibrinolytics as part of an overall strategy to limit blood loss. Several new hemostatic agents have recently come to the market designed specifically for vascular surgery but have found uses in other surgical fields, including orthopedics. This article reviews the mechanisms of action and best uses of various mechanical hemostats, active hemostats, flowable hemostats, and fibrin sealants for achieving hemostasis in orthopedic surgery. Mechanical and active hemostats have been reported to successfully decrease blood loss from cancellous bone, capillaries, and venules. Flowable hemostats are generally favorable for use in small spaces where the swelling capabilities of mechanical and active hemostats can be detrimental to surrounding structures. Sealants are best used for closing defects in tissues.
doi_str_mv 10.1177/15563316221134270
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10090851</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_15563316221134270</sage_id><sourcerecordid>2802426489</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-ce5236d33a97a626824aa23bd0e7f692487341ec47e6e6e53e1c98f3760558bb3</originalsourceid><addsrcrecordid>eNp9UE1Lw0AQXUSxtfoDvEhveknd701OUopaodCDel42ySRNSbJ1NxH6793SWhRB5jDDmzdvHg-ha4InhCh1T4SQjBFJKSGMU4VP0HCHRYxRfnqciRygC-_XGHMilTxHA6awFDhRQ3Q7h8b6znRVNp6W0HZ-XLXjpetWdgN5AF97V4LbXqKzwtQerg59hN6fHt9m82ixfH6ZTRdRxhLZRRkIymTOmEmUkVTGlBtDWZpjUIVMKI8V4wQyrkCGEgxIlsQFUxILEacpG6GHve6mTxvIs-DImVpvXNUYt9XWVPr3pq1WurSfmmCc4FiQoHB3UHD2owff6abyGdS1acH2XtMYU04lj5NAJXtq5qz3DorjH4L1LmH9J-Fwc_PT4PHiO9JAmOwJ3pSg17Z3bQjsH8UvvkyCHw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2802426489</pqid></control><display><type>article</type><title>Hemostatic Agents in Orthopedic Surgery</title><source>PubMed Central</source><source>SAGE</source><creator>Tanghe, Kira K. ; Chalmers, Brian P. ; Blevins, Jason L. ; Figgie, Mark P. ; Carli, Alberto V. ; Agrusa, Christopher J. ; Sculco, Peter K. ; Gausden, Elizabeth B.</creator><creatorcontrib>Tanghe, Kira K. ; Chalmers, Brian P. ; Blevins, Jason L. ; Figgie, Mark P. ; Carli, Alberto V. ; Agrusa, Christopher J. ; Sculco, Peter K. ; Gausden, Elizabeth B.</creatorcontrib><description>Controlling blood loss is a crucial aspect of orthopedic surgery. Hemostatic agents can be used intraoperatively in combination with antifibrinolytics as part of an overall strategy to limit blood loss. Several new hemostatic agents have recently come to the market designed specifically for vascular surgery but have found uses in other surgical fields, including orthopedics. This article reviews the mechanisms of action and best uses of various mechanical hemostats, active hemostats, flowable hemostats, and fibrin sealants for achieving hemostasis in orthopedic surgery. Mechanical and active hemostats have been reported to successfully decrease blood loss from cancellous bone, capillaries, and venules. Flowable hemostats are generally favorable for use in small spaces where the swelling capabilities of mechanical and active hemostats can be detrimental to surrounding structures. Sealants are best used for closing defects in tissues.</description><identifier>ISSN: 1556-3316</identifier><identifier>EISSN: 1556-3324</identifier><identifier>DOI: 10.1177/15563316221134270</identifier><identifier>PMID: 37065097</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Review</subject><ispartof>HSS Journal, 2023-05, Vol.19 (2), p.247-253</ispartof><rights>The Author(s) 2022</rights><rights>The Author(s) 2022.</rights><rights>The Author(s) 2022 2022 Hospital for Special Surgery</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-ce5236d33a97a626824aa23bd0e7f692487341ec47e6e6e53e1c98f3760558bb3</citedby><cites>FETCH-LOGICAL-c396t-ce5236d33a97a626824aa23bd0e7f692487341ec47e6e6e53e1c98f3760558bb3</cites><orcidid>0000-0002-4561-7587</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090851/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10090851/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,313,314,727,780,784,792,885,27922,27924,27925,53791,53793,79236</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37065097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanghe, Kira K.</creatorcontrib><creatorcontrib>Chalmers, Brian P.</creatorcontrib><creatorcontrib>Blevins, Jason L.</creatorcontrib><creatorcontrib>Figgie, Mark P.</creatorcontrib><creatorcontrib>Carli, Alberto V.</creatorcontrib><creatorcontrib>Agrusa, Christopher J.</creatorcontrib><creatorcontrib>Sculco, Peter K.</creatorcontrib><creatorcontrib>Gausden, Elizabeth B.</creatorcontrib><title>Hemostatic Agents in Orthopedic Surgery</title><title>HSS Journal</title><addtitle>HSS J</addtitle><description>Controlling blood loss is a crucial aspect of orthopedic surgery. Hemostatic agents can be used intraoperatively in combination with antifibrinolytics as part of an overall strategy to limit blood loss. Several new hemostatic agents have recently come to the market designed specifically for vascular surgery but have found uses in other surgical fields, including orthopedics. This article reviews the mechanisms of action and best uses of various mechanical hemostats, active hemostats, flowable hemostats, and fibrin sealants for achieving hemostasis in orthopedic surgery. Mechanical and active hemostats have been reported to successfully decrease blood loss from cancellous bone, capillaries, and venules. Flowable hemostats are generally favorable for use in small spaces where the swelling capabilities of mechanical and active hemostats can be detrimental to surrounding structures. Sealants are best used for closing defects in tissues.</description><subject>Review</subject><issn>1556-3316</issn><issn>1556-3324</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9UE1Lw0AQXUSxtfoDvEhveknd701OUopaodCDel42ySRNSbJ1NxH6793SWhRB5jDDmzdvHg-ha4InhCh1T4SQjBFJKSGMU4VP0HCHRYxRfnqciRygC-_XGHMilTxHA6awFDhRQ3Q7h8b6znRVNp6W0HZ-XLXjpetWdgN5AF97V4LbXqKzwtQerg59hN6fHt9m82ixfH6ZTRdRxhLZRRkIymTOmEmUkVTGlBtDWZpjUIVMKI8V4wQyrkCGEgxIlsQFUxILEacpG6GHve6mTxvIs-DImVpvXNUYt9XWVPr3pq1WurSfmmCc4FiQoHB3UHD2owff6abyGdS1acH2XtMYU04lj5NAJXtq5qz3DorjH4L1LmH9J-Fwc_PT4PHiO9JAmOwJ3pSg17Z3bQjsH8UvvkyCHw</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Tanghe, Kira K.</creator><creator>Chalmers, Brian P.</creator><creator>Blevins, Jason L.</creator><creator>Figgie, Mark P.</creator><creator>Carli, Alberto V.</creator><creator>Agrusa, Christopher J.</creator><creator>Sculco, Peter K.</creator><creator>Gausden, Elizabeth B.</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4561-7587</orcidid></search><sort><creationdate>20230501</creationdate><title>Hemostatic Agents in Orthopedic Surgery</title><author>Tanghe, Kira K. ; Chalmers, Brian P. ; Blevins, Jason L. ; Figgie, Mark P. ; Carli, Alberto V. ; Agrusa, Christopher J. ; Sculco, Peter K. ; Gausden, Elizabeth B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-ce5236d33a97a626824aa23bd0e7f692487341ec47e6e6e53e1c98f3760558bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanghe, Kira K.</creatorcontrib><creatorcontrib>Chalmers, Brian P.</creatorcontrib><creatorcontrib>Blevins, Jason L.</creatorcontrib><creatorcontrib>Figgie, Mark P.</creatorcontrib><creatorcontrib>Carli, Alberto V.</creatorcontrib><creatorcontrib>Agrusa, Christopher J.</creatorcontrib><creatorcontrib>Sculco, Peter K.</creatorcontrib><creatorcontrib>Gausden, Elizabeth B.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>HSS Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanghe, Kira K.</au><au>Chalmers, Brian P.</au><au>Blevins, Jason L.</au><au>Figgie, Mark P.</au><au>Carli, Alberto V.</au><au>Agrusa, Christopher J.</au><au>Sculco, Peter K.</au><au>Gausden, Elizabeth B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemostatic Agents in Orthopedic Surgery</atitle><jtitle>HSS Journal</jtitle><addtitle>HSS J</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>19</volume><issue>2</issue><spage>247</spage><epage>253</epage><pages>247-253</pages><issn>1556-3316</issn><eissn>1556-3324</eissn><abstract>Controlling blood loss is a crucial aspect of orthopedic surgery. Hemostatic agents can be used intraoperatively in combination with antifibrinolytics as part of an overall strategy to limit blood loss. Several new hemostatic agents have recently come to the market designed specifically for vascular surgery but have found uses in other surgical fields, including orthopedics. This article reviews the mechanisms of action and best uses of various mechanical hemostats, active hemostats, flowable hemostats, and fibrin sealants for achieving hemostasis in orthopedic surgery. Mechanical and active hemostats have been reported to successfully decrease blood loss from cancellous bone, capillaries, and venules. Flowable hemostats are generally favorable for use in small spaces where the swelling capabilities of mechanical and active hemostats can be detrimental to surrounding structures. Sealants are best used for closing defects in tissues.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>37065097</pmid><doi>10.1177/15563316221134270</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4561-7587</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1556-3316
ispartof HSS Journal, 2023-05, Vol.19 (2), p.247-253
issn 1556-3316
1556-3324
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10090851
source PubMed Central; SAGE
subjects Review
title Hemostatic Agents in Orthopedic Surgery
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T03%3A42%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hemostatic%20Agents%20in%20Orthopedic%20Surgery&rft.jtitle=HSS%20Journal&rft.au=Tanghe,%20Kira%20K.&rft.date=2023-05-01&rft.volume=19&rft.issue=2&rft.spage=247&rft.epage=253&rft.pages=247-253&rft.issn=1556-3316&rft.eissn=1556-3324&rft_id=info:doi/10.1177/15563316221134270&rft_dat=%3Cproquest_pubme%3E2802426489%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c396t-ce5236d33a97a626824aa23bd0e7f692487341ec47e6e6e53e1c98f3760558bb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2802426489&rft_id=info:pmid/37065097&rft_sage_id=10.1177_15563316221134270&rfr_iscdi=true