Bisphosphonates as Potential Inhibitors of Calcification in Bioprosthetic Heart Valves (Review)

As early as 50 years ago, bisphosphonates turned from a water treatment agent into one of the most widely used groups of drugs for the treatment of various diseases of calcium metabolism (bone tissue resorption, oncological complications of neurodegenerative diseases and others). Years of research o...

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Bibliographic Details
Published in:Sovremennye tekhnologii v medit͡s︡ine 2022, Vol.14 (2), p.68-78
Main Author: Timchenko, T P
Format: Article
Language:English
Subjects:
Bone and Bones
Bone Resorption - drug therapy
Calcification, Physiologic
Calcinosis - drug therapy
Calcinosis - prevention & control
Diphosphonates - chemistry
Diphosphonates - pharmacology
Diphosphonates - therapeutic use
Heart Valves
Humans
Reviews
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Summary:As early as 50 years ago, bisphosphonates turned from a water treatment agent into one of the most widely used groups of drugs for the treatment of various diseases of calcium metabolism (bone tissue resorption, oncological complications of neurodegenerative diseases and others). Years of research on bisphosphonates have contributed to the understanding of their molecular and cellular pathways of their action. All bisphosphonates have a similar structure and common properties, however, there are obvious chemical, biochemical, and pharmacological differences between them. Each bisphosphonate has its own unique profile. This review summarizes data on the mechanisms of action of bisphosphonates, demonstrates the experience and prospects for their use for the modification of cardiovascular bioprostheses, since the issue of preventing bisphosphonate calcification has not been settled yet.
ISSN:2076-4243
2309-995X
DOI:10.17691/stm2022.14.2.07