Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents

Introduction: Hepatitis C (HCV) is associated with extra-hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown. Methods: Chronic hepatitis C (CHC) indivi...

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Bibliographic Details
Published in:Journal of Virus Eradication 2023-03, Vol.9 (1), p.100318
Main Authors: Cheng, Pin-Nan, Sun, Hung-Yu, Feng, I-Che, Wang, Sin-Tian, Chiu, Yen-Cheng, Chiu, Hung-Chih, Chien, Shih-Chieh, Young, Kung-Chia
Format: Article
Language:English
Subjects:
hepatitis C
Liver stiffness measurement
Original Research
Oxidized low-density lipoprotein
Post-SVR
Spontaneous clearance
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Summary:Introduction: Hepatitis C (HCV) is associated with extra-hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown. Methods: Chronic hepatitis C (CHC) individuals receiving DAA treatment with SVR were compared to those who underwent spontaneous clearance (SC) of HCV infection at the 2-year follow-up. Plasma oxidative stress markers (oxidized low-density lipoprotein (oxLDL), 8-hydroxy-2′-deoxyguanosine (8-OHdG), malondialdehyde (MDA) and ischemia-modified albumin (IMA)) as well as progression of liver fibrosis were evaluated. Results: Compared to SC individuals, those in the CHC group exhibited at baseline higher levels of oxLDL, 8-OHdG and IMA but not of MDA. In the SC group, 8-OHdG levels were elevated at 2-year post-SVR (p = 0.0409), while the DAA-treated CHC group showed decrease in oxLDL (p 
ISSN:2055-6640
2055-6659
DOI:10.1016/j.jve.2023.100318