Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents

Introduction: Hepatitis C (HCV) is associated with extra-hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown. Methods: Chronic hepatitis C (CHC) indivi...

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Published in:Journal of Virus Eradication 2023-03, Vol.9 (1), p.100318
Main Authors: Cheng, Pin-Nan, Sun, Hung-Yu, Feng, I-Che, Wang, Sin-Tian, Chiu, Yen-Cheng, Chiu, Hung-Chih, Chien, Shih-Chieh, Young, Kung-Chia
Format: Article
Language:English
Subjects:
hepatitis C
Liver stiffness measurement
Original Research
Oxidized low-density lipoprotein
Post-SVR
Spontaneous clearance
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container_issue 1
container_start_page 100318
container_title Journal of Virus Eradication
container_volume 9
creator Cheng, Pin-Nan
Sun, Hung-Yu
Feng, I-Che
Wang, Sin-Tian
Chiu, Yen-Cheng
Chiu, Hung-Chih
Chien, Shih-Chieh
Young, Kung-Chia
description Introduction: Hepatitis C (HCV) is associated with extra-hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown. Methods: Chronic hepatitis C (CHC) individuals receiving DAA treatment with SVR were compared to those who underwent spontaneous clearance (SC) of HCV infection at the 2-year follow-up. Plasma oxidative stress markers (oxidized low-density lipoprotein (oxLDL), 8-hydroxy-2′-deoxyguanosine (8-OHdG), malondialdehyde (MDA) and ischemia-modified albumin (IMA)) as well as progression of liver fibrosis were evaluated. Results: Compared to SC individuals, those in the CHC group exhibited at baseline higher levels of oxLDL, 8-OHdG and IMA but not of MDA. In the SC group, 8-OHdG levels were elevated at 2-year post-SVR (p = 0.0409), while the DAA-treated CHC group showed decrease in oxLDL (p 
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Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown. Methods: Chronic hepatitis C (CHC) individuals receiving DAA treatment with SVR were compared to those who underwent spontaneous clearance (SC) of HCV infection at the 2-year follow-up. Plasma oxidative stress markers (oxidized low-density lipoprotein (oxLDL), 8-hydroxy-2′-deoxyguanosine (8-OHdG), malondialdehyde (MDA) and ischemia-modified albumin (IMA)) as well as progression of liver fibrosis were evaluated. Results: Compared to SC individuals, those in the CHC group exhibited at baseline higher levels of oxLDL, 8-OHdG and IMA but not of MDA. In the SC group, 8-OHdG levels were elevated at 2-year post-SVR (p = 0.0409), while the DAA-treated CHC group showed decrease in oxLDL (p &lt; 0.0001) and 8-OHdG (p = 0.0255) levels, approaching those of the SC group, but increased MDA (p = 0.0055) levels. Additionally, oxLDL levels were positively correlated with liver stiffness measurements at SVR (p = 0.017) and at 1 year post- SVR (p = 0.002). Conclusions: Plasma oxLDL showed post-SVR normalization after clearance of HCV viremia with DAAs and was associated with levels of hepatic fibrosis.</description><identifier>ISSN: 2055-6640</identifier><identifier>EISSN: 2055-6659</identifier><identifier>DOI: 10.1016/j.jve.2023.100318</identifier><language>eng</language><publisher>Elsevier</publisher><subject>hepatitis C ; Liver stiffness measurement ; Original Research ; Oxidized low-density lipoprotein ; Post-SVR ; Spontaneous clearance</subject><ispartof>Journal of Virus Eradication, 2023-03, Vol.9 (1), p.100318</ispartof><rights>2023 The Authors 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-50423d86e2777e18c76c802719fba46d5f0ab9010c277ab82ee65a886387987c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091014/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10091014/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Cheng, Pin-Nan</creatorcontrib><creatorcontrib>Sun, Hung-Yu</creatorcontrib><creatorcontrib>Feng, I-Che</creatorcontrib><creatorcontrib>Wang, Sin-Tian</creatorcontrib><creatorcontrib>Chiu, Yen-Cheng</creatorcontrib><creatorcontrib>Chiu, Hung-Chih</creatorcontrib><creatorcontrib>Chien, Shih-Chieh</creatorcontrib><creatorcontrib>Young, Kung-Chia</creatorcontrib><title>Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents</title><title>Journal of Virus Eradication</title><description>Introduction: Hepatitis C (HCV) is associated with extra-hepatic involvment, morbidity as well as metabolic changes. Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown. Methods: Chronic hepatitis C (CHC) individuals receiving DAA treatment with SVR were compared to those who underwent spontaneous clearance (SC) of HCV infection at the 2-year follow-up. Plasma oxidative stress markers (oxidized low-density lipoprotein (oxLDL), 8-hydroxy-2′-deoxyguanosine (8-OHdG), malondialdehyde (MDA) and ischemia-modified albumin (IMA)) as well as progression of liver fibrosis were evaluated. Results: Compared to SC individuals, those in the CHC group exhibited at baseline higher levels of oxLDL, 8-OHdG and IMA but not of MDA. In the SC group, 8-OHdG levels were elevated at 2-year post-SVR (p = 0.0409), while the DAA-treated CHC group showed decrease in oxLDL (p &lt; 0.0001) and 8-OHdG (p = 0.0255) levels, approaching those of the SC group, but increased MDA (p = 0.0055) levels. Additionally, oxLDL levels were positively correlated with liver stiffness measurements at SVR (p = 0.017) and at 1 year post- SVR (p = 0.002). 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Whether these might be reversible if sustained virologic response (SVR) is achieved by direct-acting antiviral (DAA) therapy remains unknown. Methods: Chronic hepatitis C (CHC) individuals receiving DAA treatment with SVR were compared to those who underwent spontaneous clearance (SC) of HCV infection at the 2-year follow-up. Plasma oxidative stress markers (oxidized low-density lipoprotein (oxLDL), 8-hydroxy-2′-deoxyguanosine (8-OHdG), malondialdehyde (MDA) and ischemia-modified albumin (IMA)) as well as progression of liver fibrosis were evaluated. Results: Compared to SC individuals, those in the CHC group exhibited at baseline higher levels of oxLDL, 8-OHdG and IMA but not of MDA. In the SC group, 8-OHdG levels were elevated at 2-year post-SVR (p = 0.0409), while the DAA-treated CHC group showed decrease in oxLDL (p &lt; 0.0001) and 8-OHdG (p = 0.0255) levels, approaching those of the SC group, but increased MDA (p = 0.0055) levels. 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subjects hepatitis C
Liver stiffness measurement
Original Research
Oxidized low-density lipoprotein
Post-SVR
Spontaneous clearance
title Reversibility of some oxidative stress markers in chronic hepatitis C patients after receiving direct-acting antiviral agents
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