Rheumatoid arthritis and Hailey‐Hailey disease treated with methotrexate

We report a rare case of long‐standing Hailey‐Hailey disease in a Caucasian Portuguese 69‐year‐old woman, recently diagnosed with rheumatoid arthritis. The patient's skin lesions remained active and exudative despite topical and oral treatments with corticosteroids, tetracyclines, antifungals,...

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Bibliographic Details
Published in:International journal of rheumatic diseases 2023-01, Vol.26 (1), p.157-159
Main Authors: Mestre, Beatriz, Garcia, Jorge, Madruga Dias, João
Format: Article
Language:English
Subjects:
Aged
Arthritis, Rheumatoid - diagnosis
Arthritis, Rheumatoid - drug therapy
Azathioprine
Azathioprine - therapeutic use
Case Report
Case Reports
Corticosteroids
Female
Hailey‐Hailey disease
Humans
Methotrexate
Methotrexate - therapeutic use
Patients
Pemphigus, Benign Familial - diagnosis
Pemphigus, Benign Familial - drug therapy
Pemphigus, Benign Familial - pathology
Quality of Life
Rheumatoid arthritis
Skin diseases
Skin lesions
Tetracyclines
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Summary:We report a rare case of long‐standing Hailey‐Hailey disease in a Caucasian Portuguese 69‐year‐old woman, recently diagnosed with rheumatoid arthritis. The patient's skin lesions remained active and exudative despite topical and oral treatments with corticosteroids, tetracyclines, antifungals, and oral treatment with azathioprine. After introduction of methotrexate for rheumatoid arthritis treatment, the skin lesions regressed, with significant impact on the patient's quality of life. This case report supports the clinical evidence of methotrexate's potential role in Hailey‐Hailey disease treatment.
ISSN:1756-1841
1756-185X
DOI:10.1111/1756-185X.14456