Independent Reproduction of the FLASH Effect on the Gastrointestinal Tract: A Multi-Institutional Comparative Study

FLASH radiation therapy (RT) is a promising new paradigm in radiation oncology. However, a major question that remains is the robustness and reproducibility of the FLASH effect when different irradiators are used on animals or patients with different genetic backgrounds, diets, and microbiomes, all...

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Bibliographic Details
Published in:Cancers 2023-04, Vol.15 (7), p.2121
Main Authors: Valdés Zayas, Anet, Kumari, Neeraj, Liu, Kevin, Neill, Denae, Delahoussaye, Abagail, Gonçalves Jorge, Patrik, Geyer, Reiner, Lin, Steven H, Bailat, Claude, Bochud, François, Moeckli, Raphael, Koong, Albert C, Bourhis, Jean, Taniguchi, Cullen M, Herrera, Fernanda G, Schüler, Emil
Format: Article
Language:English
Subjects:
Abdomen
Acute effects
Animals
Diarrhea
Gastrointestinal system
Gastrointestinal tract
Health aspects
Laboratories
Medical research
Methods
Microbiomes
Radiation
Radiation therapy
Radiotherapy
Reproducibility
Small intestine
Statistical analysis
Survival analysis
Testing
Toxicity
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Summary:FLASH radiation therapy (RT) is a promising new paradigm in radiation oncology. However, a major question that remains is the robustness and reproducibility of the FLASH effect when different irradiators are used on animals or patients with different genetic backgrounds, diets, and microbiomes, all of which can influence the effects of radiation on normal tissues. To address questions of rigor and reproducibility across different centers, we analyzed independent data sets from The University of Texas MD Anderson Cancer Center and from Lausanne University (CHUV). Both centers investigated acute effects after total abdominal irradiation to C57BL/6 animals delivered by the FLASH Mobetron system. The two centers used similar beam parameters but otherwise conducted the studies independently. The FLASH-enabled animal survival and intestinal crypt regeneration after irradiation were comparable between the two centers. These findings, together with previously published data using a converted linear accelerator, show that a robust and reproducible FLASH effect can be induced as long as the same set of irradiation parameters are used.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15072121