Extracellular Vesicles Act as Carriers for Cargo Delivery and Regulate Wnt Signaling in the Hepatocellular Carcinoma Tumor Microenvironment

As the primary type of liver cancer, hepatocellular carcinoma (HCC) causes a large number of deaths every year. Despite extensive research conducted on this disease, the prognosis of HCC remains unclear. Recently, research has largely focused on extracellular vesicles (EVs), and they have been found...

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Bibliographic Details
Published in:Cancers 2023-03, Vol.15 (7), p.2088
Main Authors: He, Risheng, Xu, Yi, Yu, Liang, Meng, Nanfeng, Wang, Hang, Cui, Yunfu, Yam, Judy Wai Ping
Format: Article
Language:English
Subjects:
Cancer therapies
Cell signaling
Cellular signal transduction
Cytokines
Development and progression
Disease
Extracellular vesicles
Hepatocellular carcinoma
Hepatoma
Insects
Kinases
Ligands
Lipids
Liver cancer
Lymphocytes
Medical prognosis
Medical research
Medical screening
Medicine, Experimental
Mutation
Phosphorylation
Physiology
Proteins
Review
Signal transduction
Tumor microenvironment
Tumors
Wnt protein
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Summary:As the primary type of liver cancer, hepatocellular carcinoma (HCC) causes a large number of deaths every year. Despite extensive research conducted on this disease, the prognosis of HCC remains unclear. Recently, research has largely focused on extracellular vesicles (EVs), and they have been found to participate in various ways in the development of various diseases, including HCC, such as by regulating cell signaling pathways. However, recent studies have reported the mechanisms underlying the regulation of Wnt signaling by EVs in HCC, primarily focusing on the regulation of the canonical pathways. This review summarizes the current literature on the regulation of Wnt signaling by EVs in HCC and their underlying mechanisms. In addition, we also present future research directions in this field. This will deepen the understanding of HCC and provide new ideas for its treatment.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15072088