Dietary Evodiamine Inhibits Atherosclerosis-Associated Changes in Vascular Smooth Muscle Cells

is a traditional Chinese medicine. The active ingredient, evodiamine, is a quinolone alkaloid and is found in Evodiae fructus. We investigated the effect of evodiamine on atherosclerosis using mice fed on a high-fat diet and ox-LDL-induced MOVAS cell lines to construct mouse models and cell-line mod...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-04, Vol.24 (7), p.6653
Main Authors: Zha, Yiwen, Yang, Yongqi, Zhou, Yue, Ye, Bingqian, Li, Hongliang, Liang, Jingyan
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Analysis
Animal models
Animals
Arteriosclerosis
Atherosclerosis
Atherosclerosis - drug therapy
Atherosclerosis - etiology
Atherosclerosis - metabolism
Cancer
Cell activation
Cell adhesion & migration
Cell culture
Cell lines
Cell Proliferation
Coronary vessels
Development and progression
Evodia
High fat diet
Inflammation
Inflammatory response
Low density lipoprotein
Low density lipoproteins
Mice
Muscle, Smooth, Vascular - metabolism
Muscles
Myocytes, Smooth Muscle - metabolism
Oxidative stress
Phosphatidylinositol 3-Kinases - metabolism
Plaque, Atherosclerotic - metabolism
Proteins
Smooth muscle
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Summary:is a traditional Chinese medicine. The active ingredient, evodiamine, is a quinolone alkaloid and is found in Evodiae fructus. We investigated the effect of evodiamine on atherosclerosis using mice fed on a high-fat diet and ox-LDL-induced MOVAS cell lines to construct mouse models and cell-line models. We report a significant reduction in atherosclerotic plaque formation in mice exposed to evodiamine. Our mechanistic studies have revealled that evodiamine can regulate the proliferation, migration, and inflammatory response of and oxidative stress in vascular smooth muscle cells by inhibiting the activation of the PI3K/Akt axis, thus inhibiting the occurrence and development of atherosclerosis. In conclusion, our findings reveal a role for evodiamine in the regulation of vascular smooth muscle cells in atherosclerosis, highlighting a potential future role for the compound as an anti-atherosclerotic agent.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24076653