Irritable Bowel Syndrome and the Gut Microbiome: A Comprehensive Review

Irritable Bowel Syndrome (IBS) is a functional disorder of the gastrointestinal tract characterized by abdominal pain and altered bowel habits. It has a prevalence of 10 to 25% in the United States and has a high disease burden, as evidenced by reduced quality of life, decreased work productivity an...

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Published in:Journal of clinical medicine 2023-03, Vol.12 (7), p.2558
Main Authors: Shaikh, Sofia D, Sun, Natalie, Canakis, Andrew, Park, William Y, Weber, Horst Christian
Format: Article
Language:English
Subjects:
Abdomen
Analysis
Anxiety
Care and treatment
Chronic fatigue syndrome
Chronic pain
Clinical medicine
Comorbidity
Composition
Constipation
Demographic aspects
Diagnosis
Digestive system
Females
Fibromyalgia
Gastroesophageal reflux
Gastrointestinal system
Irritable bowel syndrome
Medical care, Cost of
Medical examination
Microbiota
Microbiota (Symbiotic organisms)
Nervous system
Pathogenesis
Quality of life
Review
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description Irritable Bowel Syndrome (IBS) is a functional disorder of the gastrointestinal tract characterized by abdominal pain and altered bowel habits. It has a prevalence of 10 to 25% in the United States and has a high disease burden, as evidenced by reduced quality of life, decreased work productivity and increased healthcare utilization and costs. IBS has been associated with several intra-intestinal and extra-intestinal conditions, including psychiatric comorbidities. Although the pathophysiology of IBS has not been fully elucidated, it involves dysregulation of communication between the brain and gut (brain-gut axis) which is associated with alterations in intestinal motility, gut permeability, visceral hypersensitivity and gut microbiota composition. The purpose of this article is to review the role the gut microbiota plays in the pathophysiology of IBS, understand factors that affect the gut microbiome and explore the microbiome as a target of treatment.
doi_str_mv 10.3390/jcm12072558
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subjects Abdomen
Analysis
Anxiety
Care and treatment
Chronic fatigue syndrome
Chronic pain
Clinical medicine
Comorbidity
Composition
Constipation
Demographic aspects
Diagnosis
Digestive system
Females
Fibromyalgia
Gastroesophageal reflux
Gastrointestinal system
Irritable bowel syndrome
Medical care, Cost of
Medical examination
Microbiota
Microbiota (Symbiotic organisms)
Nervous system
Pathogenesis
Quality of life
Review
title Irritable Bowel Syndrome and the Gut Microbiome: A Comprehensive Review
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