Loading…
The Crosstalk between Gut Microbiota and White Adipose Tissue Mitochondria in Obesity
Adipose tissue (AT) dysregulation is a key process in the pathophysiology of obesity and its cardiometabolic complications, but even if a growing body of evidence has been collected over recent decades, the underlying molecular basis of adiposopathy remains to be fully understood. In this context, m...
Saved in:
| Published in: | Nutrients 2023-03, Vol.15 (7), p.1723 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c474t-8b965108492127943753bdc1d200ae4fc05ebce18615a7e8f163b320096554c3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c474t-8b965108492127943753bdc1d200ae4fc05ebce18615a7e8f163b320096554c3 |
| container_end_page | |
| container_issue | 7 |
| container_start_page | 1723 |
| container_title | Nutrients |
| container_volume | 15 |
| creator | Colangeli, Luca Escobar Marcillo, David Israel Simonelli, Valeria Iorio, Egidio Rinaldi, Tommaso Sbraccia, Paolo Fortini, Paola Guglielmi, Valeria |
| description | Adipose tissue (AT) dysregulation is a key process in the pathophysiology of obesity and its cardiometabolic complications, but even if a growing body of evidence has been collected over recent decades, the underlying molecular basis of adiposopathy remains to be fully understood. In this context, mitochondria, the intracellular organelles that orchestrate energy production and undergo highly dynamic adaptive changes in response to changing environments, have emerged as crucial regulators of both white (WAT) and brown adipose tissue (BAT) metabolism and function. Given that the gut microbiota and its metabolites are able to regulate host metabolism, adipogenesis, WAT inflammation, and thermogenesis, we hypothesize that their frequently observed dysregulation in obesity could affect AT metabolism by exerting direct and indirect effects on AT mitochondria. By collecting and revising the current evidence on the connections between gut microbiota and AT mitochondria in obesity, we gained insights into the molecular biology of their hitherto largely unexplored crosstalk, tracing how gut microbiota may regulate AT mitochondrial function. |
| doi_str_mv | 10.3390/nu15071723 |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10097238</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A746947908</galeid><sourcerecordid>A746947908</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-8b965108492127943753bdc1d200ae4fc05ebce18615a7e8f163b320096554c3</originalsourceid><addsrcrecordid>eNptkltrHCEUx6W0NCHNSz9AEfpSCpt4d-apLEubBhLysqGP4jhnsqazulUnJd--DrmX6IPi-Z3_8VwQ-kjJEectOQ4TlURTzfgbtM-IZgulBH_77L6HDnO-JvPSRCv-Hu1xTUQrFdtHl-sN4FWKORc7_sYdlL8AAZ9MBZ97l2LnY7HYhh7_2vgCeNn7XcyA1z7nCSpTotvE0CdvsQ_4ooPsy-0H9G6wY4bD-_MArX98X69-Ls4uTk5Xy7OFE1qURdO1SlLSiJZRplvBteRd72jPCLEgBkckdA5oo6i0GpqBKt7xaqxuUjh-gL7dye6mbgu9g1CSHc0u-a1NtyZab15agt-Yq3hjaJWoFWuqwpd7hRT_TJCL2frsYBxtgDhlwxpCFJON5BX9_B96HacUanqm_r1VQlBNn6grO4LxYYg1sJtFzVIL1Qrdkjns0StU3T1svYsBBl_fXzh8vXNwc6sSDI9JUmLmOTBPc1DhT8_L8og-dJ3_AyRgqqY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2799644171</pqid></control><display><type>article</type><title>The Crosstalk between Gut Microbiota and White Adipose Tissue Mitochondria in Obesity</title><source>Publicly Available Content (ProQuest)</source><source>PubMed Central</source><creator>Colangeli, Luca ; Escobar Marcillo, David Israel ; Simonelli, Valeria ; Iorio, Egidio ; Rinaldi, Tommaso ; Sbraccia, Paolo ; Fortini, Paola ; Guglielmi, Valeria</creator><creatorcontrib>Colangeli, Luca ; Escobar Marcillo, David Israel ; Simonelli, Valeria ; Iorio, Egidio ; Rinaldi, Tommaso ; Sbraccia, Paolo ; Fortini, Paola ; Guglielmi, Valeria</creatorcontrib><description>Adipose tissue (AT) dysregulation is a key process in the pathophysiology of obesity and its cardiometabolic complications, but even if a growing body of evidence has been collected over recent decades, the underlying molecular basis of adiposopathy remains to be fully understood. In this context, mitochondria, the intracellular organelles that orchestrate energy production and undergo highly dynamic adaptive changes in response to changing environments, have emerged as crucial regulators of both white (WAT) and brown adipose tissue (BAT) metabolism and function. Given that the gut microbiota and its metabolites are able to regulate host metabolism, adipogenesis, WAT inflammation, and thermogenesis, we hypothesize that their frequently observed dysregulation in obesity could affect AT metabolism by exerting direct and indirect effects on AT mitochondria. By collecting and revising the current evidence on the connections between gut microbiota and AT mitochondria in obesity, we gained insights into the molecular biology of their hitherto largely unexplored crosstalk, tracing how gut microbiota may regulate AT mitochondrial function.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu15071723</identifier><identifier>PMID: 37049562</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adenosine ; Adipocytes ; Adipogenesis ; Adipose tissue ; Adipose tissue (brown) ; Adipose Tissue, Brown - metabolism ; Adipose Tissue, White - metabolism ; Angiogenesis ; Atherosclerosis ; Body fat ; Changing environments ; Chronic illnesses ; Cold ; Complications ; Energy ; Energy Metabolism ; Environmental changes ; Gastrointestinal Microbiome - physiology ; Glucose ; Histology ; Homeostasis ; Humans ; Hyperplasia ; Insulin resistance ; Intestinal microflora ; Lipids ; Metabolic disorders ; Metabolism ; Metabolites ; Microbiota ; Microorganisms ; Mitochondria ; Mitochondria - metabolism ; Molecular biology ; Obesity ; Obesity - metabolism ; Organelles ; Review ; Thermogenesis ; Thermogenesis - physiology ; Tomography ; Weight control</subject><ispartof>Nutrients, 2023-03, Vol.15 (7), p.1723</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-8b965108492127943753bdc1d200ae4fc05ebce18615a7e8f163b320096554c3</citedby><cites>FETCH-LOGICAL-c474t-8b965108492127943753bdc1d200ae4fc05ebce18615a7e8f163b320096554c3</cites><orcidid>0000-0002-8603-664X ; 0000-0001-7807-5190 ; 0000-0002-6912-7814 ; 0000-0001-6673-3838 ; 0000-0001-6206-8498</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2799644171/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2799644171?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37049562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Colangeli, Luca</creatorcontrib><creatorcontrib>Escobar Marcillo, David Israel</creatorcontrib><creatorcontrib>Simonelli, Valeria</creatorcontrib><creatorcontrib>Iorio, Egidio</creatorcontrib><creatorcontrib>Rinaldi, Tommaso</creatorcontrib><creatorcontrib>Sbraccia, Paolo</creatorcontrib><creatorcontrib>Fortini, Paola</creatorcontrib><creatorcontrib>Guglielmi, Valeria</creatorcontrib><title>The Crosstalk between Gut Microbiota and White Adipose Tissue Mitochondria in Obesity</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Adipose tissue (AT) dysregulation is a key process in the pathophysiology of obesity and its cardiometabolic complications, but even if a growing body of evidence has been collected over recent decades, the underlying molecular basis of adiposopathy remains to be fully understood. In this context, mitochondria, the intracellular organelles that orchestrate energy production and undergo highly dynamic adaptive changes in response to changing environments, have emerged as crucial regulators of both white (WAT) and brown adipose tissue (BAT) metabolism and function. Given that the gut microbiota and its metabolites are able to regulate host metabolism, adipogenesis, WAT inflammation, and thermogenesis, we hypothesize that their frequently observed dysregulation in obesity could affect AT metabolism by exerting direct and indirect effects on AT mitochondria. By collecting and revising the current evidence on the connections between gut microbiota and AT mitochondria in obesity, we gained insights into the molecular biology of their hitherto largely unexplored crosstalk, tracing how gut microbiota may regulate AT mitochondrial function.</description><subject>Adenosine</subject><subject>Adipocytes</subject><subject>Adipogenesis</subject><subject>Adipose tissue</subject><subject>Adipose tissue (brown)</subject><subject>Adipose Tissue, Brown - metabolism</subject><subject>Adipose Tissue, White - metabolism</subject><subject>Angiogenesis</subject><subject>Atherosclerosis</subject><subject>Body fat</subject><subject>Changing environments</subject><subject>Chronic illnesses</subject><subject>Cold</subject><subject>Complications</subject><subject>Energy</subject><subject>Energy Metabolism</subject><subject>Environmental changes</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Glucose</subject><subject>Histology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Insulin resistance</subject><subject>Intestinal microflora</subject><subject>Lipids</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Molecular biology</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Organelles</subject><subject>Review</subject><subject>Thermogenesis</subject><subject>Thermogenesis - physiology</subject><subject>Tomography</subject><subject>Weight control</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptkltrHCEUx6W0NCHNSz9AEfpSCpt4d-apLEubBhLysqGP4jhnsqazulUnJd--DrmX6IPi-Z3_8VwQ-kjJEectOQ4TlURTzfgbtM-IZgulBH_77L6HDnO-JvPSRCv-Hu1xTUQrFdtHl-sN4FWKORc7_sYdlL8AAZ9MBZ97l2LnY7HYhh7_2vgCeNn7XcyA1z7nCSpTotvE0CdvsQ_4ooPsy-0H9G6wY4bD-_MArX98X69-Ls4uTk5Xy7OFE1qURdO1SlLSiJZRplvBteRd72jPCLEgBkckdA5oo6i0GpqBKt7xaqxuUjh-gL7dye6mbgu9g1CSHc0u-a1NtyZab15agt-Yq3hjaJWoFWuqwpd7hRT_TJCL2frsYBxtgDhlwxpCFJON5BX9_B96HacUanqm_r1VQlBNn6grO4LxYYg1sJtFzVIL1Qrdkjns0StU3T1svYsBBl_fXzh8vXNwc6sSDI9JUmLmOTBPc1DhT8_L8og-dJ3_AyRgqqY</recordid><startdate>20230331</startdate><enddate>20230331</enddate><creator>Colangeli, Luca</creator><creator>Escobar Marcillo, David Israel</creator><creator>Simonelli, Valeria</creator><creator>Iorio, Egidio</creator><creator>Rinaldi, Tommaso</creator><creator>Sbraccia, Paolo</creator><creator>Fortini, Paola</creator><creator>Guglielmi, Valeria</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8603-664X</orcidid><orcidid>https://orcid.org/0000-0001-7807-5190</orcidid><orcidid>https://orcid.org/0000-0002-6912-7814</orcidid><orcidid>https://orcid.org/0000-0001-6673-3838</orcidid><orcidid>https://orcid.org/0000-0001-6206-8498</orcidid></search><sort><creationdate>20230331</creationdate><title>The Crosstalk between Gut Microbiota and White Adipose Tissue Mitochondria in Obesity</title><author>Colangeli, Luca ; Escobar Marcillo, David Israel ; Simonelli, Valeria ; Iorio, Egidio ; Rinaldi, Tommaso ; Sbraccia, Paolo ; Fortini, Paola ; Guglielmi, Valeria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-8b965108492127943753bdc1d200ae4fc05ebce18615a7e8f163b320096554c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adenosine</topic><topic>Adipocytes</topic><topic>Adipogenesis</topic><topic>Adipose tissue</topic><topic>Adipose tissue (brown)</topic><topic>Adipose Tissue, Brown - metabolism</topic><topic>Adipose Tissue, White - metabolism</topic><topic>Angiogenesis</topic><topic>Atherosclerosis</topic><topic>Body fat</topic><topic>Changing environments</topic><topic>Chronic illnesses</topic><topic>Cold</topic><topic>Complications</topic><topic>Energy</topic><topic>Energy Metabolism</topic><topic>Environmental changes</topic><topic>Gastrointestinal Microbiome - physiology</topic><topic>Glucose</topic><topic>Histology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Insulin resistance</topic><topic>Intestinal microflora</topic><topic>Lipids</topic><topic>Metabolic disorders</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Mitochondria</topic><topic>Mitochondria - metabolism</topic><topic>Molecular biology</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Organelles</topic><topic>Review</topic><topic>Thermogenesis</topic><topic>Thermogenesis - physiology</topic><topic>Tomography</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colangeli, Luca</creatorcontrib><creatorcontrib>Escobar Marcillo, David Israel</creatorcontrib><creatorcontrib>Simonelli, Valeria</creatorcontrib><creatorcontrib>Iorio, Egidio</creatorcontrib><creatorcontrib>Rinaldi, Tommaso</creatorcontrib><creatorcontrib>Sbraccia, Paolo</creatorcontrib><creatorcontrib>Fortini, Paola</creatorcontrib><creatorcontrib>Guglielmi, Valeria</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colangeli, Luca</au><au>Escobar Marcillo, David Israel</au><au>Simonelli, Valeria</au><au>Iorio, Egidio</au><au>Rinaldi, Tommaso</au><au>Sbraccia, Paolo</au><au>Fortini, Paola</au><au>Guglielmi, Valeria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Crosstalk between Gut Microbiota and White Adipose Tissue Mitochondria in Obesity</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2023-03-31</date><risdate>2023</risdate><volume>15</volume><issue>7</issue><spage>1723</spage><pages>1723-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Adipose tissue (AT) dysregulation is a key process in the pathophysiology of obesity and its cardiometabolic complications, but even if a growing body of evidence has been collected over recent decades, the underlying molecular basis of adiposopathy remains to be fully understood. In this context, mitochondria, the intracellular organelles that orchestrate energy production and undergo highly dynamic adaptive changes in response to changing environments, have emerged as crucial regulators of both white (WAT) and brown adipose tissue (BAT) metabolism and function. Given that the gut microbiota and its metabolites are able to regulate host metabolism, adipogenesis, WAT inflammation, and thermogenesis, we hypothesize that their frequently observed dysregulation in obesity could affect AT metabolism by exerting direct and indirect effects on AT mitochondria. By collecting and revising the current evidence on the connections between gut microbiota and AT mitochondria in obesity, we gained insights into the molecular biology of their hitherto largely unexplored crosstalk, tracing how gut microbiota may regulate AT mitochondrial function.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37049562</pmid><doi>10.3390/nu15071723</doi><orcidid>https://orcid.org/0000-0002-8603-664X</orcidid><orcidid>https://orcid.org/0000-0001-7807-5190</orcidid><orcidid>https://orcid.org/0000-0002-6912-7814</orcidid><orcidid>https://orcid.org/0000-0001-6673-3838</orcidid><orcidid>https://orcid.org/0000-0001-6206-8498</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6643 |
| ispartof | Nutrients, 2023-03, Vol.15 (7), p.1723 |
| issn | 2072-6643 2072-6643 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10097238 |
| source | Publicly Available Content (ProQuest); PubMed Central |
| subjects | Adenosine Adipocytes Adipogenesis Adipose tissue Adipose tissue (brown) Adipose Tissue, Brown - metabolism Adipose Tissue, White - metabolism Angiogenesis Atherosclerosis Body fat Changing environments Chronic illnesses Cold Complications Energy Energy Metabolism Environmental changes Gastrointestinal Microbiome - physiology Glucose Histology Homeostasis Humans Hyperplasia Insulin resistance Intestinal microflora Lipids Metabolic disorders Metabolism Metabolites Microbiota Microorganisms Mitochondria Mitochondria - metabolism Molecular biology Obesity Obesity - metabolism Organelles Review Thermogenesis Thermogenesis - physiology Tomography Weight control |
| title | The Crosstalk between Gut Microbiota and White Adipose Tissue Mitochondria in Obesity |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T05%3A07%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Crosstalk%20between%20Gut%20Microbiota%20and%20White%20Adipose%20Tissue%20Mitochondria%20in%20Obesity&rft.jtitle=Nutrients&rft.au=Colangeli,%20Luca&rft.date=2023-03-31&rft.volume=15&rft.issue=7&rft.spage=1723&rft.pages=1723-&rft.issn=2072-6643&rft.eissn=2072-6643&rft_id=info:doi/10.3390/nu15071723&rft_dat=%3Cgale_pubme%3EA746947908%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c474t-8b965108492127943753bdc1d200ae4fc05ebce18615a7e8f163b320096554c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2799644171&rft_id=info:pmid/37049562&rft_galeid=A746947908&rfr_iscdi=true |