In vitro effect of toluene diisocyanate on beta adrenergic and muscarinic receptor function in lung tissue of the rat

To investigate the role of pharmacological mechanisms in toluene diisocyanate (TDI) induced occupational asthma, the effects of TDI on rat trachea ring and lung parenchymal strip were studied in vitro. The most prominent effect observed was a stimulation of metacholine (1 microM) induced contraction...

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Bibliographic Details
Published in:British Journal of Industrial Medicine 1989-01, Vol.46 (1), p.56-59
Main Authors: Borm, P J, Bast, A, Zuiderveld, O P
Format: Article
Language:English
Subjects:
Agonists
Allergies
Animals
Asthma
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Cyanates - toxicity
Diisocyanates
Dose response relationship
In Vitro Techniques
Lung - drug effects
Lung diseases
Lungs
Male
Medical sciences
Pharmacology
Rats
Rats, Inbred Strains
Receptors, Adrenergic, beta - drug effects
Receptors, Muscarinic - drug effects
Toluene 2,4-Diisocyanate - toxicity
Toxicology
Trachea
Trachea - drug effects
Various organic compounds
Washing
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Summary:To investigate the role of pharmacological mechanisms in toluene diisocyanate (TDI) induced occupational asthma, the effects of TDI on rat trachea ring and lung parenchymal strip were studied in vitro. The most prominent effect observed was a stimulation of metacholine (1 microM) induced contraction of the tracheal ring by 1 microM TDI (added in dimethy sulphoxide). The results were less pronounced when TDI was added from a stock solution prepared in water, which is possibly due to (co)polymerisation. It is concluded that the pharmacological effect of TDI may result from an autonomic imbalance between cholinergic and beta-adrenergic neural control.
ISSN:0007-1072
1351-0711
1470-7926
DOI:10.1136/oem.46.1.56