Multiple sclerosis and occupational exposure to chemicals: a co-twin control study of a nationwide series of twins

From the Finnish Twin Cohort (n = 27,100 pairs with known zygosity) all cases of diagnosed multiple sclerosis (MS) were reviewed and those with clinically verified MS were invited for further examinations at the Institute of Occupational Health, Helsinki, with their co-twins. Twenty one cases (19 pa...

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Bibliographic Details
Published in:British Journal of Industrial Medicine 1989-06, Vol.46 (6), p.417-419
Main Authors: Juntunen, J, Kinnunen, E, Antti-Poika, M, Koskenvuo, M
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Chemical hazards
Chemical Industry
Chemical mixtures
Cohort Studies
Disease risk
Diseases in Twins
Epidemiology
Female
Finland
General aspects
Humans
Lead
Lead - adverse effects
Male
Medical sciences
Middle Aged
Multiple sclerosis
Multiple Sclerosis - chemically induced
Nervous system diseases
Neurology
Occupational Diseases - chemically induced
Occupational health and safety
Solvents
Solvents - adverse effects
Toxicology
Trichloroethylene - adverse effects
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Summary:From the Finnish Twin Cohort (n = 27,100 pairs with known zygosity) all cases of diagnosed multiple sclerosis (MS) were reviewed and those with clinically verified MS were invited for further examinations at the Institute of Occupational Health, Helsinki, with their co-twins. Twenty one cases (19 pairs, of which 17 were discordant) fulfilled the strict criteria of MS. Detailed occupational history showed exposure to a mixture of solvents in six subjects, to lead in one, and to trichloroethylene in one. Of these seven, two monozygotic twins had MS whereas the other five cases were healthy co-twins. These results do not support a causal association between occupational exposure to chemicals and the aetiopathogenesis of MS.
ISSN:0007-1072
1351-0711
1470-7926
DOI:10.1136/oem.46.6.417