Incidence, treatment and outcome of central nervous system relapse in adult acute lymphoblastic leukaemia patients treated front‐line with paediatric‐inspired regimens: A retrospective multicentre Campus ALL study

Summary Within the Campus ALL network we analyzed the incidence, characteristics, treatment and outcome of a central nervous system (CNS) relapse in 1035 consecutive adult acute lymphoblastic leukemia (ALL) patients treated frontline with pediatric‐inspired protocols between 2009 and 2020. Seventy‐o...

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Bibliographic Details
Published in:British journal of haematology 2023-02, Vol.200 (4), p.440-450
Main Authors: Dargenio, Michelina, Bonifacio, Massimiliano, Chiaretti, Sabina, Vitale, Antonella, Fracchiolla, Nicola Stefano, Papayannidis, Cristina, Giglio, Fabio, Salutari, Prassede, Audisio, Ernesta, Scappini, Barbara, Zappasodi, Patrizia, Defina, Marzia, Forghieri, Fabio, Scattolin, Anna Maria, Todisco, Elisabetta, Lunghi, Monia, Guolo, Fabio, Del Principe, Maria Ilaria, Annunziata, Mario, Lazzarotto, Davide, Cedrone, Michele, Pasciolla, Crescenza, Imovilli, Annalisa, Tanasi, Ilaria, Trappolini, Silvia, Cerrano, Marco, La Starza, Roberta, Krampera, Mauro, Di Renzo, Nicola, Candoni, Anna, Pizzolo, Giovanni, Ferrara, Felicetto, Foà, Robin
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
adult ALL
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Central Nervous System
Central Nervous System Neoplasms - drug therapy
Central Nervous System Neoplasms - epidemiology
Chemotherapy
CNS relapse
Haematological Malignancy‐clinical
Hematology
Humans
Incidence
Lymphatic leukemia
Male
Multivariate analysis
Nervous system
Original Paper
paediatric‐like regimens
Patients
Pediatrics
Phenotypes
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - radiotherapy
Prophylaxis
Radiation therapy
Recurrence
Remission
Risk factors
Treatment Outcome
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Summary:Summary Within the Campus ALL network we analyzed the incidence, characteristics, treatment and outcome of a central nervous system (CNS) relapse in 1035 consecutive adult acute lymphoblastic leukemia (ALL) patients treated frontline with pediatric‐inspired protocols between 2009 and 2020. Seventy‐one patients (6.8%) experienced a CNS recurrence, more frequently in T‐ (28/278; 10%) than in B‐ALL (43/757; 5.7%) (p = 0.017). An early CNS relapse—< 12 months from diagnosis—was observed in 41 patients. In multivariate analysis, risk factors for early CNS relapse included T‐cell phenotype (p = 100 × 109/L (p
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.18537