Prediagnostic Appearance of Thrombospondin Type-1 Domain 7A Autoantibodies in Membranous Nephropathy

The entire extracellular domain of thrombospondin type-1 domain 7A (THSD7A) in the luciferase immunoprecipitation system immunoassay was required to detect autoantibodies with high sensitivity in membranous nephropathy (MN). In THSD7A-seropositive MN patients, changes in antibody levels precede chan...

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Bibliographic Details
Published in:Kidney360 2023-02, Vol.4 (2), p.217-225
Main Authors: Burbelo, Peter D, Olson, Stephen W, Keller, Jason M, Joshi, Megha, Schwartz, Daniella M, Chuang, Yung-Jen, Lambeau, Gérard, Beck, Jr, Laurence H, Waldman, Meryl
Format: Article
Language:English
Subjects:
Autoantibodies
Glomerular and Tubulointerstitial Diseases
Glomerulonephritis, Membranous - diagnosis
Humans
Original Investigation
Thrombospondins
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Summary:The entire extracellular domain of thrombospondin type-1 domain 7A (THSD7A) in the luciferase immunoprecipitation system immunoassay was required to detect autoantibodies with high sensitivity in membranous nephropathy (MN). In THSD7A-seropositive MN patients, changes in antibody levels precede changes in clinical status. Seropositive THSD7A antibodies were detected in some patients with MN considered to be secondary to autoimmunity or cancer.
ISSN:2641-7650
2641-7650
DOI:10.34067/KID.0005112022