Eight‐hour time‐restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized control trial

Objective This study aimed to assess the impact of time‐restricted eating (TRE) on integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates in males with overweight/obesity. Methods A total of 18 healthy males (age 46 ±  5 years; BMI: 30 ± 2 kg/m2) completed this exploratory, parallel...

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Published in:Obesity (Silver Spring, Md.) Md.), 2023-02, Vol.31 (S1), p.116-126
Main Authors: Parr, Evelyn B., Kouw, Imre W. K., Wheeler, Michael J., Radford, Bridget E., Hall, Rebecca C., Senden, Joan M., Goessens, Joy P. B., Loon, Luc J. C., Hawley, John A.
Format: Article
Language:English
Subjects:
Adult
Biopsy
Blood Glucose - metabolism
Blood Glucose Self-Monitoring
Body composition
Body mass index
Diet
Eating behavior
Energy
Exercise
Glucose monitoring
Humans
Male
Meals
Metabolism
Middle Aged
Muscle, Skeletal - metabolism
Musculoskeletal system
Obesity
Obesity - metabolism
Original
ORIGINAL ARTICLES
Overweight
Physical fitness
Protein synthesis
Proteins
Weight control
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Summary:Objective This study aimed to assess the impact of time‐restricted eating (TRE) on integrated skeletal muscle myofibrillar protein synthesis (MyoPS) rates in males with overweight/obesity. Methods A total of 18 healthy males (age 46 ±  5 years; BMI: 30 ± 2 kg/m2) completed this exploratory, parallel, randomized dietary intervention after a 3‐day lead‐in diet. Participants then consumed an isoenergetic diet (protein: ~1.0 g/kg body mass per day) following either TRE (10:00 a.m. to 6:00 p.m.) or an extended eating control (CON; 8:00 a.m. to 8:00 p.m.) protocol for 10 days. Integrated MyoPS rates were measured using deuterated water administration with repeated saliva, blood, and muscle sampling. Secondary measures included continuous glucose monitoring and body composition (dual‐energy x‐ray absorptiometry). Results There were no differences in daily integrated MyoPS rates (TRE: 1.28% ± 0.18% per day, CON: 1.26% ± 0.22% per day; p = 0.82) between groups. From continuous glucose monitoring, 24‐hour total area under the curve was reduced following TRE (−578 ± 271 vs. CON: 12 ± 272 mmol/L × 24 hours; p = 0.001). Total body mass declined (TRE: −1.6 ± 0.9 and CON: −1.1 ± 0.7 kg; p 
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.23637