The value of serum TRAP1 in diagnosing small cell lung cancer and tumor immunity

This study set out to investigate the clinical significance of serum tumor necrosis factor receptor-associated protein 1 (TRAP1) in diagnosing small cell lung cancer (SCLC) with different clinical stages, and to compare the diagnostic efficiency with neuron-specific enolase (NSE), carcinoembryonic a...

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Published in:Experimental biology and medicine (Maywood, N.J.) N.J.), 2023-02, Vol.248 (3), p.201-208
Main Authors: Tan, Li-Ming, Ke, Shi-Peng, Li, Xu, Ouyang, Tang-Lin, Yu, Li-Qing, Yu, Jia-Li, Wang, Ya-Kun, Yang, Qi-Jun, Li, Xiao-Hang, Yu, Xia, Li, Hua, Hu, Xiao-Yan
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - analysis
CA-19-9 Antigen
Carcinoembryonic Antigen
Carcinoma, Non-Small-Cell Lung - pathology
HSP90 Heat-Shock Proteins
Humans
Lung Neoplasms - pathology
Original Research
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Summary:This study set out to investigate the clinical significance of serum tumor necrosis factor receptor-associated protein 1 (TRAP1) in diagnosing small cell lung cancer (SCLC) with different clinical stages, and to compare the diagnostic efficiency with neuron-specific enolase (NSE), carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9). Besides, to analyze the role of serum TRAP1 in tumor immunity. A total of 91 patients with SCLC, 99 patients with non–small cell lung cancer (NSCLC), 102 patients with pulmonary nodules (PN), and 75 healthy people were included. The concentrations of serum TRAP1 was detected by enzyme-linked immunosorbent assay (ELISA). NSE, CEA, and CA19-9 were detected by chemiluminescence. The results showed that level of TRAP1 in Group SCLC was lower than other three groups (P 
ISSN:1535-3702
1535-3699
DOI:10.1177/15353702221142614