Peritoneal recurrence after resection for Stage I–III colorectal cancer: A population analysis

• Published in: Journal of surgical oncology 2023-03, Vol.127 (4), p.678-687
• Main Authors: Aiken, Taylor, Hu, Chung‐Yuan, Uppal, Abhineet, Francescatti, Amanda B., Fournier, Keith F., Chang, George J., Zafar, Syed Nabeel
• Format: Article
• Language: English
• Subjects: Adenocarcinoma, Mucinous - pathology; Carcinoma, Signet Ring Cell - pathology; Cohort Studies; Colorectal; Colorectal cancer; Colorectal Neoplasms - pathology; Colorectal Neoplasms - surgery; Histology; Humans; mucinous; Neoplasm Staging; Peritoneal Neoplasms - pathology; Peritoneal Neoplasms - surgery; peritoneal recurrence; Peritoneum - pathology; Retrospective Studies; signet ring
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.27175

Background Colorectal cancer (CRC) often recurs in the peritoneum, although the pattern of peritoneal recurrence (PR) has received less attention. We sought to describe the presentation and risk factors for PR following CRC resection. Methods We performed a cohort study of patients undergoing resection of Stage I–III CRC from 2006 to 2007 using merged data from a Commission on Cancer Special Study and the National Cancer Database. We estimated the timing, method of detection, and risk factors for isolated PR. Results Here, 8991 patients were included and isolate PR occurred in 77 (0.9%) patients. The median time to PR was 16.2 months (intrquartile range = 9.3–28.0 months) and most patients were identified via new symptoms (36.4%). Pathologic factors associated with increased odds of PR included higher T stage (T3 vs. T2, odds ratio [OR] = 4.8, 95% confidence interval [CI] = 1.5–15.7), N stage (N1 vs. N0, OR = 2.00, CI = 1.1–3.7), and signet ring (OR = 8.2, CI = 3.0–22.3) or mucinous histology (OR = 2.6, CI = 1.5–4.7). Conclusions The majority of PR was detected within 18 months and few were identified by surveillance. Advanced T/N stage and signet ring/mucinous histology were associated with increased odds of PR.