Prevalence and prognostic significance of vitamin C deficiency in patients with acute upper gastrointestinal bleeding: a prospective cohort study

Summary Background Vitamin C is an essential dietary nutrient important for collagen synthesis, including within the gastrointestinal tract. Aim We aimed to document the prevalence of Vitamin C deficiency (VCD) in patients who present with upper gastrointestinal bleeding (UGIB) and its association w...

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Published in:Alimentary pharmacology & therapeutics 2023-02, Vol.57 (3), p.313-322
Main Authors: Hui, Samuel, Lim, Andy, Koh, Elaine, Abasszade, Joshua, Morgan, Aparna, Tan, Pei Y., Lemoh, Christopher, Robertson, Marcus
Format: Article
Language:English
Subjects:
Ascorbic acid
Ascorbic Acid - therapeutic use
Ascorbic Acid Deficiency - complications
Ascorbic Acid Deficiency - epidemiology
Bleeding
Clinical outcomes
Cohort analysis
Collagen
Dietary supplements
Gastrointestinal Hemorrhage - diagnosis
Gastrointestinal Hemorrhage - epidemiology
Gastrointestinal tract
Humans
Male
Middle Aged
Mortality
Nutrient deficiency
Original
Patients
peptic ulcer disease
Prevalence
Prognosis
Prospective Studies
Regression analysis
upper gastrointestinal bleeding
varices
Vitamin C
Vitamin C Deficiency and Upper GI Bleeding
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Summary:Summary Background Vitamin C is an essential dietary nutrient important for collagen synthesis, including within the gastrointestinal tract. Aim We aimed to document the prevalence of Vitamin C deficiency (VCD) in patients who present with upper gastrointestinal bleeding (UGIB) and its association with clinical outcomes. Methods We conducted a prospective cohort study of patients presenting with UGIB. Fasting Vitamin C levels were collected at admission. Primary outcomes were the prevalence of VCD (Vitamin C level
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.17359