Curcumin-resveratrol nano-formulation counteracting hyperammonemia in rats

Malnutrition and low dietary protein intake could be risk factors for developing peripheral and central hyperammonemia, especially in pediatrics. Both curcumin and resveratrol proved to be effective against several hepatic and cerebral injuries. They were reported to be beneficial in lowering circul...

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Bibliographic Details
Published in:Metabolic brain disease 2023-04, Vol.38 (4), p.1365-1377
Main Authors: Nasr, Maha, Ahmed-farid, Omar A.H., Ahmed, Rania F.
Format: Article
Language:English
Subjects:
Ammonia
Animals
Bioavailability
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain
Brain damage
Brain injury
Child
Complications
Curcumin
Curcumin - pharmacology
Curcumin - therapeutic use
Diet
Dietary intake
Dietary Proteins
DNA damage
Emulsions
Functional foods & nutraceuticals
Humans
Hyperammonemia
Hyperammonemia - drug therapy
Liver
Low protein diet
Male
Malnutrition
Metabolic Diseases
Monoamines
Nanoemulsions
Neurology
Neurosciences
Nitric oxide
Nutrient deficiency
Oncology
Original
Original Article
Pediatrics
Proteins
Rats
Resveratrol
Resveratrol - pharmacology
Resveratrol - therapeutic use
Risk factors
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Summary:Malnutrition and low dietary protein intake could be risk factors for developing peripheral and central hyperammonemia, especially in pediatrics. Both curcumin and resveratrol proved to be effective against several hepatic and cerebral injuries. They were reported to be beneficial in lowering circulating ammonia levels, yet both are known for their low bioavailability. The use of pharmaceutical nano-formulations as delivery systems for these two nutraceuticals could solve the aforementioned problem. Hence, the present study aimed to investigate the valuable outcome of using a combination of curcumin and resveratrol in a nanoemulsion formulation, to counteract protein-deficient diet (PDD)-induced hyperammonemia and the consequent complications in male albino rats. Results revealed that using a nanoemulsion containing both curcumin and resveratrol at a dose of (5 + 5 mg/kg) effectively reduced hepatic and brain ammonia levels, serum ALT and AST levels, hepatic and brain nitric oxide levels, oxidative DNA damage as well as disrupted cellular energy performance. In addition, there was a substantial increase in brain levels of monoamines, and a decrease in glutamate content. Therefore, it can be concluded that the use of combined curcumin and resveratrol nanoemulsion is an effective means of ameliorating the hepatic and cerebral adverse effects resulting from PDD-induced hyperammonemia in rats.
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-023-01162-1