Efficacy and Safety of Tirzepatide in Adults With Type 2 Diabetes: A Perspective for Primary Care Providers

This article reviews the efficacy and safety data of tirzepatide, a once-weekly, novel glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 (GLP-1) receptor agonist approved in the United States, the European Union, and other regions for the treatment of type 2 diabetes. All dose...

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Bibliographic Details
Published in:Clinical diabetes 2023-04, Vol.41 (2), p.258-272
Main Authors: Kushner, Pamela, Anderson, John E, Simon, Jörg, Boye, Kristina S, Ranta, Kari, Torcello-Gómez, Amelia, Levine, Joshua A
Format: Article
Language:English
Subjects:
Antidiabetics
Diabetes
Disease management
Drug therapy
FDA approval
GLP-1 receptor agonists
Glucose
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Summary:This article reviews the efficacy and safety data of tirzepatide, a once-weekly, novel glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 (GLP-1) receptor agonist approved in the United States, the European Union, and other regions for the treatment of type 2 diabetes. All doses of tirzepatide demonstrated superiority in reducing A1C and body weight from baseline versus placebo or active comparators. The safety profile of tirzepatide was consistent with that of the GLP-1 receptor agonist class, with mild to moderate and transient gastrointestinal side effects being the most common adverse events. With clinically and statistically significant reductions in A1C and body weight without increased risk of hypoglycemia in various populations, tirzepatide has demonstrated potential as a first-in-class treatment option for many people with type 2 diabetes.
ISSN:0891-8929
1945-4953
DOI:10.2337/cd22-0029