Narrative engineering of the liver

Liver organoids are primary or pluripotent stem cell-derived three-dimensional structures that recapitulate regenerative or ontogenetic processes in vitro towards biomedical applications including disease modelling and diagnostics, drug safety and efficacy prediction, and therapeutic use. The cellul...

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Bibliographic Details
Published in:Current opinion in genetics & development 2022-08, Vol.75, p.101925-101925, Article 101925
Main Authors: Lee, Inkyu S, Takebe, Takanori
Format: Article
Language:English
Subjects:
developmental biology
Liver
liver organoid
narrative engineering
Organoids
pluripotent stem cell
Pluripotent Stem Cells
Reproducibility of Results
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Summary:Liver organoids are primary or pluripotent stem cell-derived three-dimensional structures that recapitulate regenerative or ontogenetic processes in vitro towards biomedical applications including disease modelling and diagnostics, drug safety and efficacy prediction, and therapeutic use. The cellular composition and structural organization of liver organoids may vary depending on the goal at hand, and the key challenge in general is to direct their development in a rational and controlled fashion for gaining targeted maturity, reproducibility, and scalability. Such endeavor begins with a detailed understanding of the biological processes in space and time behind hepatogenesis, followed by precise translation of these narrative processes through a bioengineering approach. Here, we discuss advancements in liver organoid technology through the lens of ‘narrative engineering’ in an attempt to synergize evolving understanding around molecular and cellular landscape governing hepatogenesis with engineering-inspired approaches for organoidgenesis.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2022.101925