Multifocal oral melanoacanthoma associated with Addison’s disease and hyperthyroidism: a case report

• Published in: Archives of Endocrinology and Metabolism 2017-08, Vol.61 (4), p.403-407
• Main Authors: Dantas, Thinali Sousa, Nascimento, Isabelly Vidal do, Verde, Maria Elisa Quezado Lima, Alves, Ana Paula Negreiros Nunes, Sousa, Fabrício Bitu, Mota, Mário Rogério Lima
• Format: Article
• Language: English
• Subjects: Case Report
• ISSN: 2359-3997; 2359-4292; 2359-3997; 2359-4292
• DOI: 10.1590/2359-3997000000273

Oral melanoacanthoma is a mucocutaneous, pigmented, rare, benign, and probably reactive lesion. This paper reports for the first time in the literature a case of multifocal oral melanoacanthoma in a patient diagnosed with Addison’s disease and concomitant Graves’ disease with hyperthyroidism. The patient presented with oral pigmented lesions, which were hypothesized to be mucosal pigmentation associated with Addison’s disease. Due to their unusual clinical pattern, these oral lesions were biopsied and diagnosed as oral melanoacanthoma on histopathology and immunohistochemistry for HMB-45. At the moment of this report, the patient was being treated for her systemic conditions, but the lesions had not regressed. Reactive hyperpigmentation of the skin and mucous membranes may be found in Addison’s disease and hyperthyroidism. This case reinforces the hypothesis of a reactive nature for oral melanoacanthoma and highlights the need for investigation of endocrine disorders in patients with multifocal oral melanoacanthoma.